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A Standard Business Plan Outline [Updated for Job Description 2017] This article is part of 11 Best Referral Images | Business Cards, Photography, our “Business Planning Guide” —a curated list of Preparer, our articles that will help you with the planning process! Start from the very beginning understanding that your business plan ought to Images Cards, be specific to your business needs and objectives. Every business ought to have a plan, but not every business needs a full formal plan with carefully crafted summaries and Food Job Description descriptions. Images On Pinterest. If you don’t have a specific immediate need to Preparer show a formal business plan to Referral | Business Photography a banker or investor, then you are probably better off doing just a lean business plan , for Food your internal use only. To make the A5 Wedding Planning Binder best impression on banks and Job Description investors, your business plan should be presented in the standard business plan format. Your business plan should present what a banker or venture capitalist expects to – 10+ Excel, see, in the order they expect to see it in. Following a standard business plan outline will keep you on Food, track, and save you from botching your best chance at getting your business funded.

Want to just skip ahead and Employee Word, Excel, download our free business plan template? Just click here. Preparer Job Description. I don’t recommend writing the plan in the same order you present it as a finished document. For example, although the Cv Design Ideas | Creative Cv executive summary comes as the Job Description first section of 11 Best Referral Images On Pinterest Photography, a business plan, I recommend writing it after everything else is done, so you know exactly what appears in the rest of your business plan. Preparer Job Description. Likewise, although the management summary is Wedding Planner Planning Binder, usually presented toward the Preparer end of a finished business plan, it might be an easy place to On Pinterest | Business Cards, Photography start writing. And some people prefer to start with a mission statement, or strategy summary. Others like to focus on the numbers first, so they start with a sales forecast or spending budget. Food Preparer Job Description. Start where you like, and get going.

A healthy business planning process will always involve circling back often to Images | Business Cards, Photography check results and Food revise as necessary. Letter. Notice 07 40. If you have the main components, the Food Job Description order doesn’t matter that much, but what’s presented here is the sequence I suggest for a standard business plan. In this article, I will cover the Clear, Oil Bottles following: You can click each of the above links to Preparer Job Description jump directly to that section. See an Battleships-Blank-Worksheet.jpg example of Food Preparer Job Description, a completed business plan here, and learn even more about writing a business plan here. Write this last. It’s just a page or two that highlights the points you’ve made elsewhere in Planner Printable A5 Wedding Planning Binder your business plan. Food Job Description. It’s also the doorway to your plan—after looking over Planner Printable A5 Wedding Planning, your executive summary, your target reader is Food, either going to throw your business plan away or keep reading, so you’d better get it just right. Summarize the problem you are solving for Battleships-Blank-Worksheet.jpg customers, your solution, the Food Job Description target market, the founding team, and 25+ Creative financial forecast highlights. Keep things as brief as possible and Preparer Job Description entice your audience to Planner Planning learn more about your company. Describe the Food problem that you solve for your customers and Employee Template Word, Excel, Pdf Format the solution that you are selling. It is Preparer, always a good idea to think in Battleships-Blank-Worksheet.jpg terms of Food Preparer, customer needs and 11 Best | Business Photography customer benefits as you define your product offerings, rather than thinking of your side of the equation (how much the Job Description product or service costs, and how you deliver it to the customer).

Sometimes this part of the plan will include tables that provide more details, such as a bill of Plan Images Resume, materials or detailed price lists, but more often than not this section just describes what you are selling and Preparer how your products and services fill a need for Plan | Reporter your customers. Food Job Description. You need to Employee Schedule – 10+ Free Word, Pdf Format know your target market—the types of customers you are looking for—and how it’s changing. Use this section to Food Preparer discuss your customers’ needs, where your customers are, how to reach them and how to Blank, Clear, Laser-Printer Oil Bottles deliver your product to them. You’ll also need to know who your competitors are and how you stack up against Food Preparer Job Description them—why are you sure there’s room for you in this market? Use this section to outline your marketing plan, your sales plan, and the other logistics involved in actually running your business. You’ll want to cover the Battleships-Blank-Worksheet.jpg technology you plan on using, your business location and other facilities, special equipment you might need, and your roadmap for getting your business up and running. Finally, you’ll want to Preparer outline the key metrics you’ll be tracking to Clear, Labels For Essential make sure your business is headed in the right direction. Food Job Description. This section is an Audit On Cost And Audit Of overview of who you are.

It should describe the Preparer Job Description organization of your business, and the key members of the 11 Best Images On Pinterest | Business Cards, Photography management team, but it should also ground the Job Description reader with the Images On Pinterest Cards, nuts and Preparer Job Description bolts: when your company was founded, who is/are the owner(s), what state your company is registered in Battleships-Blank-Worksheet.jpg and where you do business, and when/if your company was incorporated. Be sure to Job Description include summaries of 25+ Creative Ideas On Pinterest | Creative, your managers’ backgrounds and experience—these should act like brief resumes—and describe their functions with the company. Preparer Job Description. Full-length resumes should be appended to the plan. At the 11+ Project | Reporter Resume very least this section should include your projected profit and loss and Preparer cash flow tables, and a brief description of the assumptions you’re making with your projections. Finally, if you are raising money or taking out Cv Design Ideas | Creative Cv, loans, you should highlight the money you need to launch the Food Preparer business.

Listen to Blank, Clear, Labels For Essential Tim Berry discuss lean business planning: 2.3 Validation of Problem and Food Solution. 3.2 Target Market Segment Strategy. 25+ Creative Cv Design Ideas | Creative. 3.5.1 Competitors and Alternatives. Preparer. 4.3 Location and Audit Poject And Audit Report Of Facilities. 5.0 Company and Management Summary. 5.1 Organizational Structure. 5.5 Company History and Ownership. 6.3 Projected Profit and Loss. Food Preparer Job Description. 6.5 Projected Balance Sheet. Cash flow is the single most important numerical analysis in a business plan, and a standard cash flow table should never be missing.

Most standard business plans also include a sales forecast and Battleships-Blank-Worksheet.jpg profit and loss statements. Food Preparer. I believe they should also have a separate projected balance sheet, projected business ratios, and Employee Schedule – 10+ Free Word, Pdf Format market analysis tables, as well as personnel listings. I also believe that every business plan should include bar charts and Food Job Description pie charts to illustrate the Blank, Laser-Printer For Essential numbers. Food. Size your business plan to fit your business. Remember that your business plan should be only 25+ Creative Ideas On Pinterest | Creative, as big as what you need to Food Job Description run your business. While every business owner should have an 11 Accounting ongoing planning process to help them run their business, not every business owner needs a complete, formal business plan suitable for Job Description submitting to 11+ Project Plan Images | Reporter Resume a potential investor, or bank, or venture capital contest. Food Job Description. So don’t include outline points just because they are on 11+ Project Images Resume, a big list somewhere, or on this list, unless you’re developing a standard business plan that you’ll be showing to Job Description someone who expects to see a standard business plan. Consider lean business planning— writing a business plan doesn’t have to Battleships-Blank-Worksheet.jpg be a long, painful process. Instead, you can use the Lean Planning method to Food get started easier and Best Cv Design Cv finish faster. Food Preparer Job Description. Lean Planning will help you start your business in Battleships-Blank-Worksheet.jpg a way that improves your chances of Food, success. This methodology is Laser-Printer For Essential, baked into LivePlan . Don’t make common mistakes.

I’ve seen thousands of business plans, good and bad, and I can tell you that avoiding these common business planning errors will put you far ahead of the Food Preparer curve. 11 Best Referral Cards,. Sample business plans: Over 500 free sample business plans from various industries. Business plan template: This fill-in-the-blank business plan template is in Food Preparer the format preferred by banks and the U.S. Template Word, Excel, Pdf Format. Small Business Administration (SBA). Food Preparer. How to start a business: An easy-to-follow six-step process for starting a new business. Resignation Letter. 07 40. LivePlan: Easy cloud-based business planning software for Preparer everyone. Printable Planning. This online software includes expert advice, built-in help and more than 500 complete sample business plans.

Business plan consulting: We’re here to Preparer Job Description give you the Planning Binder tools to Job Description write your business plan on your own. Blank, Clear, For Essential. But, sometimes it’s nice to Food Preparer Job Description have a professional guide you through the Work Schedule Template – 10+ Word, Pdf Format process. Food Job Description. Let an Referral Cards, Photography expert MBA create a business plan for your business in five business days. It have really helped me a lot, I `m currently busi with starting my own company that will take the world by storm and I really need someone who is Food Job Description, not scared to Battleships-Blank-Worksheet.jpg invest on Job Description, me since I don`t have cash. Plan Images. what is the first thing you would do to start a business. Food Preparer. what are the Audit Poject On Cost Of highlights of making a business plan? im thinking about Food Preparer starting A business. The Small Business Administration has a great tool for people who are preparing to open their own businesses.

The Small Business Planner can be found at: http://www.sba.gov/smallbusinessplanner/index.html. Audit 11 Accounting And Audit Report. It has a great step by step guide on Preparer, how to prepare for Battleships-Blank-Worksheet.jpg and open a business as well as additional tips on Food Preparer, writing your business plan. Thanks for this information. Wedding Planner Printable A5 Wedding Planning Binder. The information and the sample plans really continue to boost my energy and Preparer excitment over Best Cv Design | Creative, starting my new business venture. Food Preparer. That#8217;s great. We love to hear about someone excited about Photography Entrepreneurship! Good luck to Job Description you and Best 25+ Creative Cv Design Ideas | Creative your new business! I#8217;m going to Food Job Description join HSBC young entrepreneur Award and they require a outline limited to Battleships-Blank-Worksheet.jpg 1000 words. If I use your outline model, it will be so long, won#8217;t it ? The outline is completely customizable in business plan pro. You can add topics, delete topics, rename topics and Food move topics.

You might also find some of A5 Wedding Planning Binder, our resources on writing a business plan for Preparer Job Description a competition to be helpful. Printable. Specifically: Read Tim Berry’s white paper about business plan competitions. Thank you for your question. Palo Alto Software. Thank God I found what I was looking for. how to Job Description do business plan for Official Notice 07 40 spectacles and eyeware company? This is Food Job Description, a question we get quite a lot Ashwini. #8220;How do you write a plan for Wedding A5 Wedding Planning __specific type of Food Job Description, business___#8221; We have created the bplans.com website as a resource for people to Battleships-Blank-Worksheet.jpg get the information they need to write their business plans or help in the course of their business. We don#8217;t write business plans here. Food Preparer Job Description. We aren#8217;t a consulting company. We write business planning software that walks you through writing your business plan step by step and helps you with the process of planning your business. On the Blank, Clear, bplans website you can find resources that will help you in creating a business plan for Job Description an eyeware company, but most likely, you won#8217;t find a sample plan for Referral Images On Pinterest Photography that exactly. Food Preparer Job Description. You#8217;ll find the Laser-Printer tools to write that plan yourself.

I hope this was helpful, and good luck in Food Preparer your venture! Very good guide i#8217;m doing a business plan course and Referral On Pinterest | Business Cards, Photography I found it very helpful I am useing it and Food Job Description its helping a lot very greatful for your site. Regards and best wishes for the future from Referral On Pinterest | Business, Malta. Food Job Description. THE BUSINESS PLAN SAMPLES GAVE ME A CLEAR UNDERSTANDING OF THE PRINCIPLES NEEDED IN ORDER TO PREPARE MY BUSINESS PLAN FOR A HALFWAY HOUSE DRUG REHABILITATION PROGRAM THAT I PLAN TO START. THANKS! Thanks for briefing on business plans.Learned something from Wedding Planner Planning, you.Surely i will visit again for more information. Food Job Description. If you do a search on Best 25+ Creative | Creative, the bplans.com website for Preparer SWOT you#8217;ll find several articles on the subject. Hope that helps! You can search on the bplans.com website for Printable Planning some examples of complete business plans. Hope that helps!

Thank you for your assistance it has really made my work easier.I wish there were avenues for people to send in Preparer their questions on Two Weeks, the subjectfor help as to how to Food Preparer Job Description prepare a business plan of Best 25+ Creative Cv Design Ideas On Pinterest Cv, a specific nature. Job Description. There are several resources, some even here on 11 Best Referral On Pinterest Photography, this website. You can locate the Expert Advice tab at the top of the page or by doing another Google search for Preparer Job Description forum#8217;s designed to Clear, Labels Oil Bottles assist people looking for specific help. There are also consultants you could look into, like Masterplans. Food Preparer. Thanks a great deal for Wedding Planner Printable your guidelines on writing business plans. Food Preparer. This site is Wedding Planner A5 Wedding Planning Binder, 100 times better and educative compared to Food Preparer other publications. I would be grateful if you could send me a copy or draft of Template – 10+ Free Word, Excel, Pdf Format, any real life small/medium size business plan for Food Preparer Job Description any income generating business in the retail industry.

Very helpful thanks#8230; I#8217;m in preparation of a Business Plan for Plan Resume a small scale enterprise for Preparer Job Description a financial company catering financial products and 11+ Project Plan Resume services. Any creative and Job Description innovative ideas are encouraged for my creation of On Cost Of, Business Plan. I just started an Preparer Job Description LLC and Best 25+ Creative Cv Design | Creative my biggest hang-up in writing my business plan is my financial forecast. Any suggestions would be greatly appreciated! I am looking into Food Preparer Job Description, it along with a partner to Employee Work – 10+ Free start a company that imports stand-up comedians to a certain area. This company will be based on only two persons putting money into the company and be working on a very low budget.

I have been looking over Food Job Description, the sample plans but none of Audit 11 Accounting On Cost And Audit Report, them seem to fit to what I am looking at. Preparer Job Description. Is there anybody out On Cost And Audit Report Of, there who could point me in Job Description the right direction on how to make my business plan for such a small agency? It would be great if you knew of a good template that I could go by. Any help would be great. Thanks and good luck to you all out Best 25+ Creative Ideas On Pinterest Cv, there.

There are many free sample business plans available here at Food bplans.com, browse through the list and you should find something that suits you. This is more of a question than a comment. The business plan outline is very helpful, but #8230; it#8217;s usually conceived for those who want to Best Cv Design Ideas On Pinterest start a new business. Preparer Job Description. My question is for advice on what to do with a business plan for revitalizing a dormant business in the tourist industry in Employee Work Schedule Template – 10+ Free Indonesia. Here are the Food Preparer particulars: an Audit Report. 11 Accounting Report Indonesian firm owns two big river boats that used to Food take tourists (mostly from Europe and Best On Pinterest | Creative Japan) on river explorations. Food Preparer. That has stopped because of financial mismanagement. I now have the Battleships-Blank-Worksheet.jpg opportunity to revive this business, but it needs investment for Job Description rehabilitating the boats, reviving the market, adjusting what is and can be offered to Battleships-Blank-Worksheet.jpg tourists, etc. I have no own capital, but the expertise to run something like this. It needs investment which can be in the form of Food Preparer Job Description, direct investment or a loan from Labels For Essential, a bank. WHAT WOULD BE THE MAIN POINTS OF A BUSINESS PLAN that I couold show to Food Preparer private investors or banks?

I can be reached at Report. On Cost And Audit Of [email protected] Calculating the Food value of your business is Audit Report. 11 Accounting Poject On Cost And Audit Of, vital if you are trying to find investors, apply for Preparer a loan, or sell your business to Images a potential buyer. Preparer Job Description. The Premier Edition of Clear, Labels Oil Bottles, Business Plan Pro includes detailed valuation tools that can help you determine a solid business valuation and Preparer Job Description create a professional investment offering. Showcase the true value of Audit Report. And Audit Report, your business with more advanced spreadsheets that describe the Food Preparer sources and Battleships-Blank-Worksheet.jpg uses of cash for any new or existing business. Business Plan Pro Premier Edition is recommended for an existing company.

The premier edition has advanced financials and can can forecast out Job Description, up to ten years and in detail for Clear, Labels For Essential Oil Bottles up to two years. Food Preparer Job Description. Make sure you maximize the full value of On Pinterest, your business by Food Preparer, using this option, which is only available in Resume the Premier Edition. Hope that helps! Palo Alto Software. Preparer Job Description. business plan is a guiding principal to the entrepreneur because it explains the Wedding journey of the Food Preparer organisation from the day of Audit Poject Report, start and how it will carry on with its activities. with the recent competition organisational running needs to Preparer Job Description be systematic and this can be done with help of the business plan. in order for the organisation to succeed,its like some body traveling and Battleships-Blank-Worksheet.jpg he needs vehcle for traveling and so applies to Food Job Description entrepreneur he needs the Clear, vehicle which is the Food Preparer business plan. Hi, excellent article about business plans, I#8217;m currently starting a new business and writing the 11 Best Referral business plan is one of the Food Preparer Job Description starting points for me to secure investment. Also the Report. Poject On Cost And Audit Report Of fact that you say that you don#8217;t necessarily need to follow the structure reassures me, as I won#8217;t be needing to Food Preparer Job Description but felt a little unsure about doing so. I am a painter and Battleships-Blank-Worksheet.jpg have been in Preparer Job Description the painting business for Battleships-Blank-Worksheet.jpg about twenty years. Food Job Description. I was instrumental in the starting up of the first paint company I worked for. Audit Report. 11 Accounting Poject On Cost Report Of. The steps were very basic and we made a lot money#8230;. The tools of the traid were purchased and we advertised our serviceses by Food, canvesing neighborhoods and leaving our business cards. Best 25+ Creative Cv Design On Pinterest | Creative. Now I would like to start this buissness for Food Preparer myself and I neeed to A5 Wedding Binder know how to write an effective business plan and/or a proposal to acquire more funds to Food Preparer start up.

I have purchased some of my equipment and a van, however, I still have some very cost oriented obsticals to overcome and 11+ Project | Reporter Resume I need some help. Anyone who has been in this business knows that the Job Description painting business is Laser-Printer Labels For Essential, very lucrative and can be rewarding on Preparer, many levles. I am not only 11 Best Referral Images On Pinterest | Business, good at what I do, I also like it. Is there really help out there for the minority start-up businessman? Im starting my own buisness, but right now I dont have. the Preparer Job Description capital to fund my project. Plan | Reporter. it will be a beauty supply based buisness and the. Food Preparer Job Description. area I found to run it will be perfect for this project. it has other buisnesses being built in this area, and Official the customer potential is Food Job Description, great. Here is Resignation 07 40, a great resource for Food Preparer Job Description getting the capital you need to start your business. Another great resource can be your bank. Ask them about a small business loan. Clear, Laser-Printer For Essential. How to Get the Financing for Your New Small Business: Innovative Solutions From the Experts Who Do It Everyday.

Author: Fullen, S. Hello John S. Brown, Sr., Busines Plan Pro does a great job of helping you write a business plan for Job Description start-up funding. 11 Best Referral Images | Business. Palo Alto Software. Dear Sharon Fisher, We have resources built into Job Description, Business Plan Pro to help you get funding. For example, some businesses choose to start by bringing in investors for start-up funding, while others go to a bank for Laser-Printer Labels For Essential Oil Bottles a business loan. Food. Business Plan Pro has resources built in for Official Resignation Letter. Two Weeks Notice 07 40 both approaches (the SBA loan application for bank loans, the Preparer Job Description Venture capital Database for investment sources). On Pinterest | Business. Palo Alto Software. i am want to Food Job Description establish to Schedule Free Excel, Pdf Format our own buisness in kashmir . plese suggest what plan suit for Food Job Description me .when i have not such fiancial position to develop a big buisness . 11 Best Referral Images On Pinterest Cards, Photography. I want to set up a business of Food, providing my clients with a door to door service of Clear, Laser-Printer Labels For Essential Oil Bottles, automobile Oil / Lub change while they are relaxed at Food Preparer Job Description home or office. Can some one help me with a Business / Marketing Plan.

I need a professional Plan to convince my bankers for finance and also possible investors interest in the project. SOS [email protected] Honestly, you may not find a sample plan that will exactly match your business model. You may find several that are close or related. Battleships-Blank-Worksheet.jpg. What is Food Preparer Job Description, important is that we include sample plans as idea generators and examples, not as plans that you can actually print and turn in to 25+ Creative Cv Design Ideas a bank. Food Preparer. All sample plans included are real plans. You may use them as a starting point, but even if one exactly matches your type of business, it will still have different start-up costs, location, management team and market research information. What is important is that Business Plan Pro will work to develop your own plan, for your specific business. The Windows software package Business Plan Pro is an excellent tool for developing a business plan. I hope this was helpful!

Palo Alto Software. Best 25+ Creative Cv Design Ideas On Pinterest | Creative. I wish you could create a downloadable page in application form style. Food Job Description. It is always worthwhile to Battleships-Blank-Worksheet.jpg take time assessing your business plan before you commence a new project or company: mistakes which could prove costly in practice can be eliminated painlessly on Preparer, paper! Remember that a Business Plan and Audit Report. 11 Accounting your Marketing Strategies Plan are quite different, and Preparer don#8217;t forget your cashflow forecasts, profit and A5 Wedding Planning loss projections, start-up capital, ongoing capital, buy-out plans and expansion plans, bank financing and Food Preparer Job Description sales training! Setting up business on Battleships-Blank-Worksheet.jpg, paper is quite a venture! Wow#8230;This has helped me out Food Preparer Job Description, so much on Audit 11 Accounting Poject, my business plan. Your guide-line helps#8230; Hi, I#8217;m writing a business plan for Business class, and Food Preparer Job Description it is a prety rough task.

Easy for me because my plan is Battleships-Blank-Worksheet.jpg, based on Food Job Description, averages and similarities between businesses. In my textbook though, it is Battleships-Blank-Worksheet.jpg, mentioning things that are needed in a business plan, but I am finding it really difficult to see what is the most important information to Preparer take from the paragraphs. Another thing is, I am pretty confused on how to Blank, Oil Bottles start writing a business plan, and Preparer Job Description how it should look. I can#8217;t find any samples of | Reporter, business plans! I can only Preparer Job Description, find outlines.

I really like this outline the most because it goes into detail, but I#8217;m thinking that each different headline would have to be a different paragraph or page.. or is it points? I#8217;m lost, please get back to Resume me, thanks! it seems to be helping me. Food Preparer. Business Plan Pro includes 500+ sample plans. Battleships-Blank-Worksheet.jpg. Realistically you may not find a sample plan that exactly matches your business model. You may find several in Job Description your industry that are close or related. It is 25+ Creative Cv Design Ideas On Pinterest | Creative Cv, important to understand that we include sample plans as idea generators and examples, not as plans that you can actually print and turn in to Food a bank. All sample plans included are real plans. Battleships-Blank-Worksheet.jpg. You may use them as a starting point, but even if one exactly matches your type of Food, business, it will still have different start-up costs, location, management team and market research information.

Business Plan Pro will guide you through the process with a flexible outline of about four dozen topics organized into chapters, topics, and Report. Poject subtopics, with links to the proper tables and Food Job Description charts. Each topic has a split screen option that explains what should be covered, and where to find the information. Blank, Laser-Printer Oil Bottles. With the click of a single button, you may view an Preparer example of Blank, Laser-Printer, what that topic will look like in the finished business plan. Preparer Job Description. I hope this information was helpful. Palo Alto Software. Referral Images | Business. Quite helpful am going to Preparer have a try for my very important business plan, lets see how it goes and 11 Best Images On Pinterest | Business Cards, Photography will report back immediately. Preparer Job Description. I need a business plan for Best 25+ Creative Cv Design Ideas On Pinterest | Creative Cv a ongoing patchwork shop can anyone help me thanks in advance. Just a small question, I#8217;m 20 and want to buy a business for Food Job Description 200k what chance do i have with the bank? i would like to Labels For Essential start a corier business where do i start or get same help to.make business plan. i found this bussines plan is Food Job Description, helpfull for Wedding Planner Printable A5 Wedding Binder me to pepare my bussines plan. I think u should offer a sample on Job Description, how to Report. 11 Accounting Poject Report write a business plan, rather then just having a outline.

I think u should offer a wide selection on how to write a business plan, rather then just having a outline. Job Description. Are there plans that can be used by the debt buying / collection industry?? I am on Battleships-Blank-Worksheet.jpg, the works of starting up a Wilderness Camp for youth who want ot learn about our culture and stuff. I am really enjoying it alot and it#8217;s getting me a brief description of how and where to Job Description run my business.My main goal is to teach children about races and we aren#8217;t so different so with this. It has really dug into my heart and Images On Pinterest Photography made me reach out to so many different races.And to Food Preparer Job Description me, all races are vone. I am on the works of 25+ Creative Cv Design | Creative Cv, starting up a Wilderness Camp for Food Preparer Job Description youth who want ot learn about Battleships-Blank-Worksheet.jpg our culture and Preparer Job Description stuff. I am really enjoying it alot and it#8217;s getting me a brief description of how and where to run my business.My main goal is to 11+ Project Plan | Reporter teach children about races and we aren#8217;t so different so with this.

It has really dug into my heart and made me reach out to Food Preparer Job Description so many different races.And to Images me, all races are one. Fantastic, CJ! Good luck!! Palo Alto Software. Food Preparer. My daughter has started her business successfully. Employee Work Template. Anyone of you who could use a great website, professionally developed should take a look at the link provided (www.imarkcomm.com) and discuss your needs with her.

Her designer is awesome, her translator is great and Preparer Job Description her client#8217;s websites successfully generate the traffic necessary to succeed. My wife had 4+ experience in medical billing. she as team leader in 11 Best Referral Images Photography one of the leading medical billing in chennai. currently she left job. she want to doing business in Food medical billing. I am also support her. Blank, Laser-Printer Oil Bottles. please give suggesion to Preparer Job Description me for start a medical billing business with less investment. Resignation Two Weeks. Hello Tim, I#8217;m looking for Food Preparer a business plan for Planner Printable A5 Wedding my vision which is helping women, women from Preparer Job Description, jail, battered and hurt, how would I write a business plan for this. Im impressed the summary will assist me especially because i am sourcing funding from my local bank in Nairobi Kenya. I do not have any examples but I have viewed a few different business plans that are in different industriess and 11 Best Referral On Pinterest | Business Cards, vary in size. A Business plan does not have to be a huge task although the Food bigger the Letter. Notice business, the Food Preparer Job Description more in depth the Battleships-Blank-Worksheet.jpg business plan should be. Preparer Job Description. I have heard of people that have written their bp#8217;s on Blank, Labels For Essential, cocktail napkins. Job Description. If you are just starting out and want to work from home to begin with write down your plan. You aren#8217;t going to just sit on your couch and have work fall in Employee Schedule Template – 10+ Free Excel, your lap, are you? How are you going to Preparer get the Best 25+ Creative Cv Design Cv work?

Do you already have customers lined up? How much money are you going to have to Food Preparer Job Description invest? Do you need to buy equipment? Are you going to have to hire help? These are some of the basic questions that you can write down and the answers are your business plan. Work Template – 10+ Free Pdf Format. Maybe you could start by writing the Food Preparer Job Description answers to Official Resignation Letter. Notice 07 40 Two Weeks the questions above and then sit down and ask yourself some more questions and Food Job Description then answer them. After you have compiled a list of Audit Report. Poject On Cost And Audit Report, questions and Food answers organize them by Two Weeks, using the Outline. Preparer. The bottom line you can#8217;t use someone elses business plan. – 10+ Free Pdf Format. It has to Preparer Job Description be for you and Printable your business alone.

Someone else may have answered all of those questions differntly. Be unique. Food Job Description. If you find you just can#8217;t figure it out, hire someone to Blank, For Essential Oil Bottles do it for you and Food Preparer if you do figure it out maybe you could open a business that writes business plans for other people. Oooh that sounds like a good idea I gotta go! I have something I want to write:) Geek in Report. 11 Accounting On Cost And Audit Report the Woods. sir, iam vishnu doing btech in college of engg perumon,kerala,india.i have ablog named as above.iam very much interesting in business field.so u pls give me some business articles and i will post that in my blog,in that way i can understand others abt wat business they will look like. all in all i have no plan for Job Description this, in fact i searchin also for plan. Planner Planning. I have been writing business plans for Preparer a while now, for Clear, Laser-Printer For Essential myself and Preparer Job Description others. Wondered if any one knows about Greek business plans, as I have to convert mine to the market I live in, which is Greek spaeking. If any one Knows please email [email protected] where does the SWOT anyalsis fit in? Under Market Anaysis or Strategy? i need to start up a training fascilitie for Images Resume training technical personell for Job Description two companies and a comprehensive repair and service workshop. no capital but willing and good technicians to Images | Business venture in with me. please help i have the Food Preparer training college but have to sumbit businees pplans to take over Referral On Pinterest, the fascilitie. please help me. with a good business plan.

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WHAT OF SOMEBODY WHO IS INTENDING TO START A NEW BUSINESS, WHAT WILL BE THE TONE FOR COMPANY SUMMARY AND FINANCIAL PLAN. THANKS MORE THAN A MILLION. please help me here,i have a registered business,i m now to write a business which i dont have an idea of,please someone should please help me. I have an assignment on Food, how to Employee Work Schedule Template – 10+ Free Excel, Pdf Format write a business plan, please help me. Try using this outline to get started, and if you need some examples of how to Preparer finish a certain section of your business plan, check out our sample business plans at Wedding Printable Binder http://www.bplans.com/sample_business_plans.php. I also recommend our business planning guide (http://articles.bplans.com/writing-a-business-plan/), and Food Preparer Job Description if you#8217;re having trouble making your financial graphs and staying organized, our business planning software LivePlan is pretty great, too. Plan Resume. i need a business plan summary please. I have an assignment to outline a review of Preparer, revenue, but I am totally lost and Battleships-Blank-Worksheet.jpg confused. Preparer. I have no idea of how to do this. I need the information to broken down to Cv Design Ideas On Pinterest me in kindergarten terms. Preparer. Please, I am begging please help me. Audit Report. 11 Accounting Report Of. The Biz Plan Truly enriching does act as a guide path for the Start ups. Thank you in advance. i have scoped good ideas from you advice.

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resume with patents This application claims priority of a provisional application, Ser. No. 60/008,700, filed Dec. 15, 1995. The invention relates to electronic resume storage and retrieval systems and Food Job Description methods. BACKGROUND OF THE INVENTION. Resumes are a primary communication medium between employers and job applicants (candidates). Employers annually spend billions of 11 Best Images Cards, Photography dollars to solicit resumes using newspaper advertisements, job fairs, college recruitment seminars, and other methods.

In response, job applicants spend billions more to compose, typeset, print, and ship those resumes. Unfortunately, present resume delivery practices are expensive and frustrating for job applicants. Job Description. Identifying potential employers, obtaining addresses, producing resumes for each, and finally delivering them is Clear, For Essential Oil Bottles burdensome and time-consuming. The success rate for such efforts is discouragingly low, and the associated expenses can be quite significant. Food. This makes the entire process quite inefficient from the applicant's point of Clear, Labels view. Employers, too, suffer from the inefficiencies of resume collection and handling. The solicitation, receipt, storage, management, search, and retrieval of Food Preparer Job Description dozens, hundreds, and in Battleships-Blank-Worksheet.jpg, some cases thousands of resumes can be a difficult, unwieldy, and expensive burden on the employer. Physical, paper-based resumes are often stored in desk drawers and filing cabinets. The numerous limitations of present resume practices include consumption of substantial physical space; difficulty in searching through large quantities of paper documents; the near-impossibility of correlating applicants whose resumes may vary widely in organization, content, and clarity; and the lack of Food Preparer uniformity in the search process from one practitioner to another.

From the Referral Images Cards, Photography above discussion, it is clear that a very significant need exists for an improved method of resume solicitation, sorting, delivery, handling, and management. Yet prior attempts to resolve some of Food Job Description these problems have achieved only limited success. Document scanners have been used in some attempts to reduce the Employee Schedule Free Word, Pdf Format physical space consumed by physical resumes. Food. However, search methods do not work well on scanned images because scanned resumes are stored as pictures, not searchable words or text. Optical Character Recognition (OCR) has been used in some attempts to convert paper-based resumes to pure text. However, employers are typically unwilling to forgo the traditional resume because of the widely held belief that the ability to review the Free Pdf Format format, style, and presentation of the resume itself is of value.

Still other attempts have employed the aforementioned OCR conversion to allow the use of keyword search methods on the resulting text of full resumes, in an attempt to find those which contain key words or phrases. However, such methods have proven inefficient because of the Job Description nature of written language. As just one example, an employer seeking applicants residing in the state of Indiana will find numerous false matches when searching with the standard postal service abbreviation IN. Report. 11 Accounting Poject And Audit Of. The letter pair in appears frequently in the English language (many times in this sentence alone), yet most such matches in Job Description, the full text of a resume would have little or nothing to do with the searcher's true intent. A further difficulty with keyword search methods is the requirement that the words or phrases in question must match with near-perfect accuracy. The diversity of job applicant writing skills and Images On Pinterest | Business vocabularies causes many resumes, which otherwise might describe applicants with similar attributes, to be written using very different terms and phrases. Such wide variation causes keyword search methods to often erroneously exclude qualified applicants--without notification to the searcher--while simultaneously including unqualified ones.

Prior attempts at applying computer technology to resume management have been limited in scope, applicability, and usefulness. For example, many have been intended for use only by employers, employment specialists, or headhunters. Job applicants themselves are completely excluded from accessing such systems. One prior attempt, described in U.S. Pat.

No. 5,164,897 to Clark et al. (incorporated by reference), is illustrative. The first sentence of the prior art section of this patent describes the prior art as applying to employment agencies (sometimes called search firms). The preferred embodiment section of the Food Preparer Job Description patent then describes a system designed for use by Official Resignation Letter. Two Weeks 07 40 Two Weeks such agencies and firms--without direct applicant involvement of any kind. Other attempts have allowed applicants to initially enter some data, but make no explicit provision for ongoing involvement. Such approaches can result in outdated information and questionable results. Other attempts have required the installation of specialized computer hardware and/or software, or personnel training at the employer's place of Food Preparer business. The difficulty in learning and using the system often effectively restricts access to just those who have been appropriately trained.

Other attempts have incorporated rudimentary computer-based searching methods. The most common method involves the aforementioned keyword searches on the contents of entire resumes, such as offered by Wedding Planner Printable Planning Binder Online Career Center, Indianapolis, Ind. and TMP Interactive, Framingham, Mass. The inherent limitations of such methods have already been discussed. Another attempt at incorporating computer-based searching methods is seen in the services available from Intellimatch, San Jose, Calif., (Internet address: http://www.intellimatch.com). This attempt accepts weighted ranking data provided by applicants and employers. There are several disadvantages of this type of Preparer Job Description method: First, the user interface for Referral | Business Cards, interacting with such ranking systems can be complex, non-intuitive, unfamiliar, difficult to learn, and slow to operate.

Second, there is no objective reference for ranking standards--individual applicants are asked to rank themselves, leading to an extremely subjective collection of personal opinions. Third, employers are asked to rank their requirements in a like fashion, again without reference to an objective standard. Fourth, these highly subjective data are then compared to each other, compounding assumptions upon assumptions and often yielding startlingly mismatched and valueless results. Another attempt at providing resume services on Preparer Job Description the Internet is Laser-Printer For Essential Oil Bottles provided by Beverly Hills Software, 469 South Bedford Drive, Beverly Hills, Calif. 90212, (Internet address: http://www.Bhs.Com). This attempt prompts applicants to enter text-only information using a template. However, keyword searches still involve searching the entire contents of resume data; no searching by Job Description fields is available. A visual template is provided for applicant data, but the resulting pure text is A5 Wedding sorted as one large text file, like other systems. Food. There is Work Template Free Word, Excel, Pdf Format also no provision for charging or collecting fees. Some of the aforementioned examples have attempted to incorporate various remote connection means. Such remote methods have traditionally been limited to text-only resume storage and keyword-based searches of the full resume text.

None have succeeded in addressing all of the Preparer Job Description problems described above. SUMMARY OF THE INVENTION. The invention provides a method of and apparatus for Blank, Clear, Labels storage and retrieval of resume images in a manner which preserves the appearance, organization, and information content of the Preparer Job Description original document. One embodiment of the invention provides a method of and apparatus for On Pinterest Cards, Photography storing formatted summaries or outlines of resume images, and efficient searching and subsequent selection of the resume outlines and their associated resume images. One embodiment of the invention provides a user interface for creating the aforementioned resume outlines which is based on a familiar paper-based method already in common use, thus reducing the training required to effectively use the system. One embodiment of the invention provides a method of and apparatus for computer-assisted searching of the aforementioned stored resume outlines in a manner which minimizes the Food Preparer need for specialized equipment and training.

In one embodiment, such searches can be or suspended, and resumed at a later time. One embodiment of the invention provides a method of and apparatus for enabling the automatic and Battleships-Blank-Worksheet.jpg continuous execution of the searches through resume outlines, thereby determining when a potentially qualifying applicant has entered their resume outline and resume image and enabling employers to be automatically notified thereof. One embodiment of the invention provides a method of and apparatus for coordinating the terminology and Food Job Description vocabulary used by applicants and potential employers in the entry and searching for the aforementioned resume outlines. One embodiment of the invention provides a method of and apparatus for the controlled expansion of the terminology and vocabulary used by applicants and potential employers in Work Schedule Word, Excel, Pdf Format, the entry of and Food Job Description searching of the aforementioned resume outlines. One embodiment of the invention employs modern communications systems, such as the Internet, the World Wide Web, or other commercial connectivity services, for applicant submission of outlines or resume images, or employer searches through outlines or viewing of Poject Of resume images. One embodiment of the Food Preparer invention employs modern communications systems to automatically notify applicants or employers under certain conditions, such as the expiration of a time interval or occurrence of an event.

One embodiment of the invention employs common and commercially available computer hardware and software to reduce or eliminate the need for specialized equipment by Work Word, Excel, Pdf Format and training of the applicant or employer. One embodiment of the invention employs modern communications systems for billing and payment for services. Other features of the invention will become apparent to those of ordinary skill in the art upon review of the following detailed description, claims, and drawings. BRIEF DESCRIPTION OF THE DRAWINGS. Preferred embodiments of the Food invention are described below with reference to the following accompanying drawings. FIG. 1 is a block diagram illustrating a system embodying the invention. FIG. 2 is a block diagram of a server included in the system shown in FIG.

1. FIG. 3 is an example of a resume outline form sent from the server of Wedding Planner Printable Binder FIG. 2 to an applicant's client machine included in the system of FIG. 1. FIG. 4 is an Preparer, example of a search request form sent from the server of Wedding Planner Printable A5 Wedding FIG. 2 to Food Job Description an employer's client machine included in the system of FIG.

1. FIG. 5 is an example of a summary of a resume outline sent from the server of FIG. 2 to an employer's client machine in response to a search request. FIG. 6 is an example of a vocabulary assistance process in accordance with one embodiment of the invention. FIG.

7 is an example of a resume image stored by the server of FIG. Wedding Printable A5 Wedding Binder. 2. FIGS. 8A, 8B, 9-11, 12A, 12B, and 13 define a flowchart of a process performed by the server of FIG. Job Description. 2. in accordance with one embodiment of the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS. This disclosure of the invention is Audit Poject Of submitted in furtherance of the constitutional purposes of the U.S. Patent Laws to promote the progress of Job Description science and useful arts (Article 1, Section 8) FIG, 1 shows a resume storage and Printable A5 Wedding Binder retrieval system 10 embodying the invention. The system 10 comprises a server 12 including a memory 14, and Job Description a database 16 defined in the memory 14. Schedule Free Word, Excel,. The server 12 can be a minicomputer, a microcomputer, a UNIX (TM) machine, a mainframe computer, a personal computer such as an Intel (TM) PC, 286, 386, 486, Pentium, P6, etc. (TM) personal computer or clone, or Apple (TM), Macintosh (TM), or PowerPC (TM) personal computer or clone, or any other appropriate computer.

The memory 14 is preferably long term memory (e.g. hard drive, disk drive, tape unit, CD-ROM, etc.). Food Job Description. The server 12 includes typical components (FIG. Battleships-Blank-Worksheet.jpg. 2) such as a CPU or processor 18, input devices such as a keyboard (not shown), and mouse (not shown), output devices (not shown) such as a monitor and printer, RAM 20, ROM 22, serial ports (not shown), parallel ports (not shown), and communication hardware 24, which may either be internal or external, such as internal communication cards (e.g., modem card or network card) or external communication hardware (e.g., external modem), etc. Food Job Description. In one embodiment, the Employee – 10+ Free Excel, Pdf Format communication hardware 24 connects the server 12 to the Internet, so that the server 12 defines an Internet node. More particularly in one embodiment, the server 12 is a World Wide Web server connected to the Internet. In this embodiments the server 12 has a multi-user, multi-tasking operating system such as UNIX (if the server is a UNIX machine), Windows NT, LINUX (if the server is a personal computer), etc.

The system 10 further includes a job applicant's client machine (or applicant's client machine) 26 in selective communication with the server 12. The job applicant's client machine 26 is Job Description connected to the server 12 via a communication link 28. Various possible types of communication link can be employed for the communication link 28 between the Blank, Clear, Laser-Printer For Essential server 12 and the applicant's client machine 26. For example, the Food Job Description communication link 28 can comprise a hard wired connection, a telephone connection, a satellite RF, or other wireless connection, an Internet connection, a local area network or wide area network connection, a combination of the preceding, or any other desired type of connection. Labels Oil Bottles. Many applicant's client machines 26 can communicate with the Food Job Description server 12 at the same time. Different applicant's client machines can connect with the server using different types of communication links 28. For example, one of the communication links 28 can be a hard wired connection while another one of the communication links 28 is a telephone connection. After the communication link is established, communications can take place over the link using any of various protocols, such as e-mail, FTP (file transfer protocol), TCP/IP (Internet protocol, which can be used with HTTP-hyper text transfer protocol, or GOPHER), ASCII, X-MODEM, Y-MODEM, KERMIT, any variation s on these protocols, or any other appropriate protocol. During a session, the server 12 communicates to Official Two Weeks the applicant's client machine a resume outline form 30 (FIG. 3) to be completed by a job applicant.

The form 30 has a plurality of fields 31 relevant to employment, using which typical information found on Job Description a resume is summarized by the applicant, The form 30 has fields that are similar to blanks found on traditional job application forms available from employers. In the Wedding Printable Binder illustrated embodiment, the form 30 has various sections, such as a personal information section 32, an optional information section 34, a position desired section 36, an education section 38, and an employment history section 40. Other sections can be used, as desired. Each section has various fields 31. For example, in the illustrated embodiment, the personal information section 32 has fields 39, 41, 42, 44, 46, 48, 50, 52, 54, and 56 for the job applicant's first, middle, and Preparer last names, address, city, state or province (e.g., the Wedding Printable A5 Wedding Binder two letter postal service abbreviations), zip code or postal code, phone number, fax number, and e-mail address, respectively; the Job Description optional information section 34 has fields 58, 60, 62 and 64 relating to citizenship, fields 66 and 68 relating to security clearance, and Audit Report. And Audit Of a field 70 for a social security or social insurance number; the position desired section 36 has a field 72 for job title, fields 74, 76, 78, and 80 relating to Job Description the type of employment sought (full time permanent, full time temporary, part time permanent, or part time temporary), fields 82, 84, 86, and Printable A5 Wedding 88 relating to compensation requirements, and Job Description a field 90 relating to the date when the applicant will be available for the new position, the education section 38 has fields 94, 96, 98, 100, 102, 104, 106, and 108 relating to Cards, Photography majors, degrees, school names and locations, and grade point averages (multiple copies of fields 100, 102, 104, 106 and 108 can be included for multiple colleges attended); and Preparer Job Description the employment history section 40 has fields 110, 111, 112, 114, 116, 118, and 120 for employer name, employer city, employer state or province, previous job title, start date for that position, and end date for that position (multiple copies of fields 110, 111, 112, 114, 116, 118, and Work Schedule Template – 10+ Free Pdf Format 120 can be included for multiple prior positions). Other or additional fields can be used, as desired, or synonyms can be used in place of the words shown in FIG. 3 adjacent the fields. For World Wide Web applications, the form 30 is an HTML form, and has submit and clear buttons 122 and 124 using which the applicant can either send the information from the Food Preparer filled fields to the server, or can clear the form and Employee Free Excel, start over. The form 30 further includes a vocabulary assistance button 146, the function of which is discussed below. Upon receiving the form 30, the job applicant fills in (using his/her machine 26) as many fields 31 as desired, including some mandatory information such as name and contact information (address and/or phone number) in section 32. The applicant also effects creation of a graphics file 126 (FIG.

7) of the applicant's resume for receipt by the server. The graphics file 126 contains all the formatting, fonts, and margins of Food a traditional paper resume, and is of great assistance to employers wishing to gain some insight into the professionalism of an Notice 07 40 Two Weeks, applicant. The graphics file can be, for example, in a file format identified by one of the following extensions: .GIF,.TIF (or .TIFF), .JPG (or .JPEG or .JPE),.BMP,.TGA,.EPS,.PCX or another form of graphics file that maintains the appearance, format information, and font information of the Preparer original document. The applicant can create the graphics file in Audit Poject And Audit Report, any appropriate manner at a location 134 remote from the server 12. For example, the applicant can create the graphics file using a scanner 128 (FIG. 1), by scanning his or her actual printed resume. Alternatively, the applicant can use a facsimile machine 130 (FIG. 1) to fax his or her actual printed resume to Preparer a facsimile machine 132 in the possession of the administrator of the Audit Report. And Audit Of system 10 (e.g., located at the location of the Preparer server 12).

The facsimile machine 132 creates graphics file 126 that is stored by the server. Battleships-Blank-Worksheet.jpg. In one embodiment, the system administrator can convert the graphics file from a fax format to one of the above mentioned graphics file formats. Preferably, however, the server 12 itself will automatically perform the conversion from fax format to a more appropriate format such as described in the previous paragraph, so that human intervention is not required. In this preferred embodiment, the facsimile machine 132 may comprise a fax card housed in the server 12. In another embodiment, the system administrator can receive a mail copy of a printed resume, and can scan it into the server 12 for the applicant using a scanner 133 in the possession of the system administrator (e.g., located at the location of the server 12).

The server 12 receives and stores in the database 16 the Food graphics file 126 as well as an entry defined by the summary information filled in on Laser-Printer For Essential the form 30 by the job applicant. In one embodiment, the graphics file 126 can be communicated to the server using a different protocol than was used for transmitting the summary information. For example, the summary information can be sent from the applicant's client machine 26 to the server 12 via HTML, and the graphics file 126 can be sent from Food Preparer that applicant's client machine 26 to the server 12 via e-mail. Any other combination of protocols can be used, at the applicant's option. The form 30 is useful in that it provides searchable information. Official Letter. Two Weeks 07 40. The information of the Food Preparer graphics file 126 cannot be easily searched. In addition, the form defines fields 31, so that searches can be performed by field, by prospective employers. Resignation Two Weeks. Further, the form 30 is of a format known to both applicants and Preparer Job Description employers (i.e., a format like a traditional employer's job application), so that the need for training applicants and Audit Poject On Cost employers in using the system is avoided.

Instead, applicants can easily fill the Food Preparer form 30, and Official Resignation Two Weeks Notice 07 40 Two Weeks employers can easily search the Food database. In a preferred embodiment, the employers search the database using a form 136 (FIG. 4) that is very similar in appearance to the form 30 presented to applicants The forms 30 and 136 provide a standard framework to be used by all applicants, and all employers. The server 12 associates or links the summary information entry from the form 30 with the graphics file 126 submitted by the applicant's client machine 26. In other words, if a search by an employer turns up the summary information for a particular applicant, the graphics file 126 containing an image of that applicant's resume can be easily pulled up as well. The form 30 and Battleships-Blank-Worksheet.jpg graphics file 126 may be transmitted by Food Preparer Job Description the applicant's client machine during a single session.

It is also possible that the applicant may fill out and Blank, Clear, Laser-Printer For Essential transmit the form 30 during one session, and then upload the resume image during another session. Or, the applicant could fax a resume at some later time. In other words, it is not required that the two actions occur during a single session. The system further comprises an employer's client machine 138 in selective communication with the server 12. The employer's client machine is connected to Preparer Job Description the server 12 via a communication link 140.

Various possible types of communication link can be employed for the communication link between the Employee Schedule Template – 10+ Free Word, Excel, server 12 and the employer's client machine 138. Food Preparer. For example, the communication link 140 can comprise a hard wired connection, a telephone connection, a satellite RF, or other wireless connection, an Internet connection, a local area network or wide area network connection, or any other desired type of connection. Labels. Several employer's client machines 138 can communicate with the server 12 simultaneously. Employer's client machines 138 can communicate with the server 12 at the same time that one or more applicant's client machines 26 are connected to the server 12. Different employer's client machines 138 can connect with the server 12 using different types of communication links 140. For example, one employer's client machine 138 can be communicating with the server 12 using a telephone connection, while another employer's client machine 138 communicates with the server 12 using an Internet connection. Employers may prefer to use a telephone connection, instead of an Internet connection, because of less security risk in transmitting credit card information. If an Internet connection is used, some security precautions are taken in the preferred embodiment. For example, a secure server can be used for the server 12, or encryption can be used (e.g., using PGP--pretty good privacy encryption, such as is provided by Preparer Job Description ViaCrypt (TM) software, or some other encryption method). Upon connection, the server 12 provides the employer's client machine 138 with search form 136 (FIG. 4).

The search form 136 is preferably similar to the form 30 filled by applicants, as described above, and preferably includes fields 31 corresponding to fields contained on the form filled by applicants. After filling in Binder, the search form, entering search terms in the fields of importance to the employer, the employer sends the search form to the server (e.g., by pressing a submit, send, or search button 142 on the form in a HTML application). This results in the employer's client machine 138 providing a search request to the server 12 and initiating a search of the Preparer summary information in the database 16. As was the case with the applicant's form 30, the form 136 also includes a clear button 144, in an HTML application, using which the employer can clear the form 136 and start over. The search parameters are defined by the filled search form 136 The filled search form 136 indicates which fields 31 are to be searched for Planner which keywords.

For example, based on which fields 31 are filled with which keywords, a search query can be constructed which takes the logical OR of each word contained in a field, and which takes the Preparer logical AND of each of the fields 31. Other logical and weighted combinations are possible. Employee Work Schedule – 10+ Excel,. In one embodiment, if an employer fills in US in the citizenship field, and Preparer fills in Engineer, Scientist in the job title field, a search query can be constructed requiring that qualifying applicants be U.S. On Cost Report. citizens AND be engineers OR scientists. Alternative appropriate systems for creating search queries can also be employed. For example, different fields 31 can be assigned different importance weights.

It may be more critical to Preparer have a close match in the city field in the Personal Information section than to have a close match in Official Resignation Letter. Notice 07 40, the compensation field. In one embodiment, employers are able to indicate logical connectors between keywords, such as engineer NOT chemical (e.g., if an employer is Preparer Job Description looking for any type of engineer other than a chemical engineer) In a preferred embodiment, the employer can use natural English (without logical connectors), and the server 12 creates an appropriate search query. Upon completing the search, the server 12 communicates to the employer's client machine an amount of the summary information for entries that satisfy the search parameters (search query). Preferably, contact information (e.g., name, address, phone number, e-mail, fax number, etc.) of qualifying applicants is suppressed at this stage, In one embodiment, the information presented to Work Schedule – 10+ Free Excel, the employer for each entry that satisfies the search parameters is Job Description summarized information, for easy and quick review in Audit 11 Accounting On Cost Report Of, a standardized, compact, format. An example of summarized information is shown in Food, FIG. 5. Relevancy ranking is performed in Word, Excel,, a preferred embodiment. The relevancy ranking identifies entries in Preparer, the database 16 which, while perhaps not perfectly matching the criteria specified in the search form 136, are substantially similar enough to be of potential interest to the employer. Relevancy ranking can be performed in a manner such as performed by: CPL Retrieval Engine, sold by Personal Library Systems, 2400 Research Blvd., Suite 350, Rockville, Md.

20850; NexTrieve Indexing Engine from Nexial Systems, St. Annastraat 4, 6109 RH, Ohe en Laak, The Netherlands; MetaMorph Text Retrieval Engine sold by Images | Business Cards, Thunderstone Software--EPI Inc., 11115 Edgewater Drive, Cleveland, Ohio 44102; InTEXT Retrieval Engine, sold by InTEXT Systems, 715 Sutter Street, Folsom, Calif. 95630; or Fast Data Finder, sold by Paracel Inc., 80 South Lake Avenue, Suite 650, Pasadena, Calif. 91101, or any other appropriate manner. Summarized information (as shown in FIG. 5) is provided for the best matches to the search request, after taking into Job Description, account the relevancy ranking described above The maximum number of Employee Work Schedule Word, Excel, matches supplied to the employer's client machine can be set to Food Job Description any appropriate number by Report. On Cost Report either the administrator of the system 10, or the employer performing the search. In one embodiment, the employer can request summarized information for additional, less relevant, entries than those initially presented.

The server 12 then queries the employer's client machine as to Preparer Job Description whether to present graphics files 126 of A5 Wedding Planning resumes associated with the entries that satisfy the search parameters. The server does not present the graphics files 126 of the Food resumes or the contact information for entries that satisfy the search parameters until payment is made or authorized by the employer. The employer may establish an account, and provide billing information (such as by providing a credit card number) to the administrator of the system 10 at one time, and will then be able to subsequently log in using a password, and order contact information and graphics files without having to again transmit a credit card. In this manner, the employer can connect once using a telephone connection or secure connection, transmit the billing information, and subsequently use an insecure connection. In a preferred embodiment, no password is required of employers unless they choose to On Cost Of set up an account as described above. In this preferred embodiment, they can search without establishing an account, but can only obtain contact information and graphics files if they provide billing information such as a credit card. Means other than passwords can be employed to establish secure access to the server 12.

For example, the employer can transmit to a specific IP (Internet Protocol) address, or can initiate a dialup connected to a specific telephone number and transmit billing information for that session without setting up a password. The server 12 is capable of storing employer's search requests, and periodically later repeating the search (update searching). Thus, additional entries matching the Preparer search parameters can be located in the event the database has been modified and contains new entries that satisfy the search parameters. If the employer desires the A5 Wedding Planning Binder ability to Food Job Description store search requests and perform update searches, he or she will be required by the server 12 to obtain a user name and password, so the employer can be identified by the server in a subsequent connection session. The server 12 is also capable of suspending execution of Audit And Audit a search request upon receiving a suspend request from the Preparer Job Description employer's client machine, and of resuming the search at a later time upon Wedding Planner Printable A5 Wedding, receiving a resume request from the employer's client machine 138. For example, the employer may view the summary information for Food Job Description a certain number of Work Schedule Template – 10+ Word, Excel, hits (entries that satisfy the Preparer Job Description search parameters) and wish to take a break before more closely studying the 11 Accounting Poject On Cost Report Of results, or before looking at Preparer, less relevant matches. Again, if the Official Resignation Letter. Two Weeks Notice Two Weeks employer desires the ability to suspend and later resume search requests, he or she will be required by the server 12 to obtain a user name and password, so the Food employer can be identified by the server 12 in a subsequent connection session. The server further comprises vocabulary assistance capability for Wedding Planner Printable A5 Wedding assisting an applicant in filling form 30, or for Preparer assisting an 11 Best Referral On Pinterest Photography, employer in formulating a search request using form 136. The vocabulary assistance routine provides to Job Description the applicant's or employer's client machine alternative terminology which can be selected for 11 Best Images On Pinterest filling the form 30 or the form 136. An example of vocabulary assistance is Food Preparer illustrated in FIG.

6. If the Clear, Laser-Printer For Essential applicant or employer requests vocabulary assistance while filling the job title field 72 (e.g., by pressing a vocabulary assistance button 146 or 148 while the cursor of the machine 26 or 138 is in field 72), alternative terms to those filled in the field will be presented (e.g., by presenting a menu, such as a pop-up menu, to the machine 26 or 138). The applicant or employer can then select alternative terminology from the Job Description menu, which will then be added in the field. Alternatively, instead of using the vocabulary assistance while initially filling the Planner Planning form 136, an Food Preparer Job Description, employer may be dissatisfied with the results of a search, and may then return to the form 136 and initiate vocabulary assistance on one or more of the fields. The vocabulary assistance routine of the server 12 preferably learns related terms over time. The vocabulary assistance routine can operate in a manner similar to spell check routines found in word processing programs. The server also sends reminders to applicants, after some time has passed, that they should update their summary information and graphics files.

This can be via e-mail, or any other desired manner. FIGS. 8A, 8B, 9-11, 12A, 12B, and 13 define a flow chart illustrating operation of a system according to one embodiment of the Battleships-Blank-Worksheet.jpg invention. At step S1, a determination is made as to Preparer whether a client has connected to the system. If so, the system proceeds to step S2; if not, the system proceeds to Schedule step S7. At step S2, the Food Job Description server sends a main menu to the connected client, and requests a selection. After performing step S2, the system proceeds to step S3. At step S3, a determination is made as to whether the user selected to enter new applicant data. If so, the system proceeds to step S12; if not, the system proceeds to step S4. At step S4, a determination is made as to whether the Resignation Letter. Two Weeks Notice 07 40 user selected to update existing applicant data.

If so, the system proceeds to step S25; if not, the system proceeds to step S5. At step S5, a determination is made as to Food Preparer Job Description whether the user selected to begin a new search of applicants. If so, the system proceeds to step S34; if not, the system proceeds to Battleships-Blank-Worksheet.jpg step S6. At step S6, a determination is made as to whether the user selected to Food Preparer Job Description continue a previously suspended search of applicants. If so, the Wedding Planner system proceeds to step S29; if not, the system proceeds to step S64.

At step S7, a determination is made as to whether it is time for an applicant to update the information they have provided to the server, If so, the Preparer system proceeds to step S8; if not, the system proceeds to step S9. At step S8, the server notifies applicants that it is 11 Best Referral On Pinterest | Business recommended that they update their resume information. After performing step S8, the system proceeds to step S9. At step S9, a determination is Food made as to 11 Best Referral Images | Business Photography whether it is time to continue suspended searches. If so, the system proceeds to Food step S10; if not, the system proceeds to Blank, Labels step S11. At step S10, suspended searches are performed. After performing step S10, the system proceeds to step S11. At step S11, a determination is Food made as to Blank, Clear, Laser-Printer Labels Oil Bottles whether the Job Description operator of the system has requested a system shutdown (for maintenance, or some other reason). Audit Report. 11 Accounting Poject. If so, the system shuts down; if not, the system proceeds to step S1. At step S12, a new applicant identification number is Food Preparer assigned by Audit 11 Accounting Poject Report Of the server, and the server sends to the client a request for a selection of a password After performing step S12, the Preparer Job Description system proceeds to step S13.

At step S13, the system receives a response from the client. After performing step S13, the system proceeds to step S14. At step S14, the server prepares an empty resume outline form. After performing step S14, the system proceeds to step S15. At step S15, the server sends the resume outline form to the connected client, and requests that the applicant fill out the form. After performing step S15, the Blank, Clear, Labels system proceeds to step S16.

At step S16, the server receives the response from the client. After performing step S16, the system proceeds to step S17. At step S17, a determination is made as to whether the Food Job Description client requested vocabulary assistance. Printable Binder. If so, the system proceeds to Food Job Description step S18; if not, the system proceeds to step S19. At step S18, the requested vocabulary assistance information is added to Images On Pinterest | Business Cards, Photography the resume outline form. An example of Food vocabulary assistance is shown in FIG. 6. For example, if an applicant has listed cellular and Laser-Printer For Essential satellite in the job title field, and requests vocabulary assistance for the job title field, the server will generate a list of alternative terms such as development, firmware, software, and systems, and will transmit that list to the applicant's client machine, The client can then select any of the Job Description listed vocabulary assistance terms for addition to the job title field. Vocabulary assistance is Blank, For Essential Oil Bottles available for many of the Food Job Description fields on the outline form. After performing step S18, the system proceeds to step S15.

At step S19, the Official Letter. 07 40 Two Weeks server stores the information filled in the resume outline form in Preparer, the database After performing step S19, the system proceeds to step S20. At step S20, the server sends to the client a list of available resume image reception methods and requests that the applicant select a method. After performing step S20, the system proceeds to step S21. At step S21, the Official Resignation Letter. 07 40 server receives the response from the client After performing step S21, the system proceeds to step S22. At step S22, the server prepares to receive the resume image from the Food client using the selected reception method. After performing step S22, the system proceeds to step S23. At step S23, the Work Template Free Excel, server receives the resume image. After performing step S23, the system proceeds to Food Preparer step S24. At step S24, the Oil Bottles server stores the resume image in the database.

After performing step S24, the system proceeds to step S2. At step S25, the system sends to the client a message requesting an applicant identification (user name) and password. After performing step S25, the system proceeds to step S26. At step S26, the Food Preparer server receives and verifies the password and ID. After performing step S26, the system proceeds to step S27. At step S27, the server retrieves the existing resume outline information from the database for this applicant. After performing step S27, the system proceeds to Audit Report. Poject Of step S28. At step S28, the Food Preparer Job Description server fills the empty resume outline form with the outline information retrieved from the database After performing step S28, the system proceeds to S15. At step S29, the server sends to the client a message requesting a client ID (user name) and password. After performing step S29, the system proceeds to step S30.

At step S30, the server receives and verifies the ID and password. After performing step S30, the system proceeds to step S31. At step S31, the server sends to Battleships-Blank-Worksheet.jpg the client a list of this client's suspended searches and Food Preparer Job Description requests that the client make a selection. Report. Poject On Cost And Audit Report Of. After performing step S31, the system proceeds to step S32. At step S32, the server receives the selection from the client. After performing step S32, the system proceeds to step S33. At step S33, the Food Job Description server fills the empty resume outline form with selected search criteria for the suspended search which was selected for execution. After performing step S33, the system proceeds to Report. Report step S35.

At step S34, the Food server prepares an Blank, Laser-Printer Labels For Essential, empty resume outline form. After performing step S34, the system proceeds to step S35. At step S35, the server sends an Job Description, outline form to the client and requests that the client return the form with desired search criteria. After performing step S35, the system proceeds to step S36. At step S36, the server receives the response from the Wedding Planner Printable A5 Wedding Planning client After performing step S36, the Food Preparer Job Description server proceeds to step S37. At step S37, a determination is made as to whether the client requested vocabulary assistance. Battleships-Blank-Worksheet.jpg. If so, the system proceeds to step S45; if not, the system proceeds to step S38. At step S38, a determination is made as to whether the client requested suspension of the search.

If so, the system proceeds to step S46; if not, the system proceeds to step S39. At step S39, the server searches the database of existing resume outline information After performing step S39, the system proceeds to step S40. At step S40, the server summarizes compliant resume outlines, sends the summarized outlines to the client, and requests desired action. For example, the desired action can be a request that the employer select whether to modify the search, or to view a entire (not summarized) outline satisfying the Job Description search parameters. After performing step S40, the Wedding Planner A5 Wedding Binder system proceeds to step S41.

At step S41, the server receives the response from the client. After performing step S41, the system proceeds to Food Preparer step S42. At step S42, a determination is made as to whether the client chose to Audit Report. 11 Accounting Poject On Cost Report modify the search criteria. If so, the system proceeds to step S35; if not, the system proceeds to step S43. At step S43, a determination is made as to whether the client chose to view an Food Job Description, entire outline. If so, the Blank, Laser-Printer Oil Bottles system proceeds to step S44; if not, the system proceeds to step S40. At step S44, the Food server sends to the client a list of available resume outline delivery methods, and request selection by the client.

After performing step S44, the system proceeds to step S49. At step S45, requested vocabulary assistance is added to the resume outline form. Wedding A5 Wedding. After performing step S45, the system proceeds to step S35. At step S46, the server sends to the client a request for Job Description client ID (user name) and password. Wedding A5 Wedding Planning. After performing step S46, the Food Job Description system proceeds to Template Free Excel, Pdf Format step S47. At step S47, the server receives and verifies the client ID and password. After performing step S47, the system proceeds to step S48. At step S48, the server stores the search criteria.

After performing step S48, the system proceeds to step S2. At step S49, the Food Preparer server receives the response from the client. After performing step S49, the Wedding Planner Binder system proceeds to Preparer step S50. At step S50, the server sends a complete resume outline to Referral Images On Pinterest the client. By complete resume outline, what is meant is non-summarized information, in a format such as is shown in FIG. 3, except with contact information suppressed.

After performing step S50, the Food Preparer Job Description system proceeds to step S51. At step S51, a determination is made as to whether the client chose to purchase the resume image associated with the resume outline that matched the search criteria. Wedding Planner. If so, the system proceeds to step S52; if not, the Preparer Job Description system proceeds to Wedding Planner Printable step S40. At step S52, the server sends to the client a message asking if the employer has an existing account, After performing step S52, the system proceeds to Food Preparer Job Description step S53. At step S53, the Referral Images On Pinterest | Business Photography server receives the Food Preparer Job Description response from the client. After performing step S53, the Work Schedule Template Word, system proceeds to step S54. At step S54, a determination is Food Preparer made as to whether the client indicated that employer does have an existing account. If so, the system proceeds to Battleships-Blank-Worksheet.jpg step S55; if not, the system proceeds to Food Preparer Job Description step S61. At step S55, the server sends to 11 Best | Business Photography the client a request for account ID and password. After performing step S55, the system proceeds to Food Preparer step S56.

At step S56, the Battleships-Blank-Worksheet.jpg server receives and verifies the response. After performing step S56, the system proceeds to step S57. At step S57, the server sends to the client a list of available resume image delivery methods, and requests selection of one of those methods. After performing step S57, the system proceeds to step S58. At step S58, the server receives the response from the client. After performing step S58, the system proceeds to step S59. At step S59, the server retrieves the resume image from the database. After performing step S59, the system proceeds to step S60. At step S60, the Food Preparer Job Description server delivers the resume image to the client via the method selected by 11 Best On Pinterest | Business Cards, Photography the employer After performing step S60, the Preparer system proceeds to step S40. At step S61, the server sends to Resignation Two Weeks 07 40 the client a request for a credit card or other billing information.

After performing step S61, the system proceeds to step S62. At step S62, the server receives the response from the client. After performing step S62, the system proceeds to step S63. At step S63, a determination is made as to whether the client's billing information can be confirmed by a bank or other appropriate financial institution. If so, the system proceeds to step S57; if not, the system proceeds to step S52. At step S64, a determination is made as to whether there has been inactivity for too long of a time. If so, the system proceeds to step S65; if not, the system proceeds to step S2. At step S65, any searches that are in Food Preparer Job Description, progress are suspended, and Notice 07 40 Two Weeks the connection is Food Preparer Job Description terminated with respect to this client. In compliance with the statute, the invention has been described in language more or less specific as to structural and methodical features. It is to be understood, however, that the invention is not limited to the specific features shown and Resignation 07 40 described, since the means herein disclosed comprise preferred forms of putting the invention into effect.

The invention is, therefore, claimed in Food Preparer, any of A5 Wedding its forms or modifications within the Food Preparer Job Description proper scope of the appended claims appropriately interpreted in accordance with the doctrine of equivalents.

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10 Free Business Plan Templates for Preparer Job Description Startups. Planner Printable A5 Wedding Planning Binder! Business plans can seem daunting to someone who has never written one. The business idea itself might be fairly simple to explain, but if you want to Preparer apply for a loan, raise investor capital, or simply have a solid, documented direction for your company, you#39;re going to need to write a business plan. Resignation Notice 07 40! Luckily for entrepreneurs, there are templates out there that allow you to plug in all of the information, instead of Food Preparer, struggling with formatting and figuring out what you need to include. There are web-based business plan tools, but you may find it easier to use Microsoft Word and PDF-based templates. Here are 10 free templates you can download and Audit 11 Accounting Poject And Audit use to create your first business plan. [See Related Story: The Dos and Preparer Job Description Don#39;ts of Blank, Laser-Printer Labels Oil Bottles, Writing a Great Business Plan] Bplans.com, known as the authority on business plans, offers a free Word business plan template, complete with instructions and a table of Food Preparer Job Description, contents.

It also offers standard business plan sections such as executive summary, company summary, products and services, market analysis, strategy, management summary, and financial planning. Once you register, you will be able to download the materials and choose from Blank, Laser-Printer For Essential, a wide range of businesses in Food Preparer different industries in Official Letter. Notice which to Food Job Description base your plan. Whether your business is online, service-based, or a food establishment, Bplan#39;s Word business plan templates are comprehensive and Two Weeks are a great option for beginners and new business owners. Entrepreneur.com provides business tools, with a collection of business plans free in Food PDF, PowerPoint and Word. The templates can be viewed can downloaded through the SeamlessDocs platform. The site includes a template for Blank, Laser-Printer Labels For Essential Oil Bottles a variety of specific business types, a business plan model that outlines the different parts of a business plan, and customizable templates that allow users to add their logos and business information. If you need a guide to Preparer writing a business plan, Entrepreneur.com also provides a download for Clear, Laser-Printer For Essential Oil Bottles that. Food Preparer Job Description! This step-by-step business plan builder, offered by Law Depot, covers structure, product marketing, SWOT (strengths, weaknesses, opportunities, threats), operations, and Audit Report. Poject details specific to Food Preparer Job Description your business in their templates. Once the template is complete, you can download and print. The plan builder asks specific questions to help focus your answers and makes your business plan concise and comprehensive.

MOBI, or My Own Business Institute, is part of Santa Clara University#39;s Center for Innovation and Entrepreneurship. Planner Printable A5 Wedding Planning! They offer a fifteen-section business plan template, including the business profile, licenses/permits and location, which are available for free download in Word as individual templates, or as a larger all-in-one document. All download are compatible with current and older versions of Word (2003 and earlier). MOBI also covers topics associated with startups, but also provides information on how to run a business, including employee management, how to handle problems, and e-commerce. Office Depot#39;s Business Resource Center contains free business plan samples for retailers, manufacturers and service providers.

The business tools include downloadable rich text format (RTF) business plan templates, which is Word compatible. Excel business plan financials are also available for manufacturers and service providers, while the retailer business plan template is complete with forecasting and financial tables, but this requires Microsoft Word version 6.0 or later. Catering to Food Job Description businesses owned by Notice women, Oprah.com#39;s free one-page business plan templates can be used by anyone who wants to start a business. The PDF templates come filled in Preparer Job Description with example information for small consulting businesses, boutique clothing stores and nonprofit organizations, but you can delete that information to be left with a template that works for any business venture. The template has space for information such as vision, mission statement, objectives, strategies and action plans. When you create a free business plan with Rocket Lawyer, you get the advantage of an attorney#39;s advice to make sure your document is legally sound. Audit Poject Report Of! The template is questionnaire-style and asks for key information about your business such as founders, structure and industry, marketing plans, financial projections, etc. Job Description! Rocket Lawyer not only 11 Accounting On Cost Report Of aims at helping you create a blueprint for your business, but also for investors. Your completed document is available for download as a Word document for free with a trial subscription, which can be cancelled during the one-week trial period at no charge.

The document is Preparer, $10 on its own without a subscription. Laser-Printer For Essential! SCORE is a small business resource website that aims to help entrepreneurs launch and grow small business across the United States. Their collection of business planning tools includes free Word business plan templates for startups and established businesses. They also provide a sales forecasting template, competitive analysis charts to determine your business#39; strengths and Food weaknesses, and Resignation Two Weeks financial planning templates such as startup expenses, profit and loss projections, and financial statements. You can then use these business templates to meet with a Score mentor for expert business planning advice. Preparer Job Description! The Small Business Administration (SBA) offers an online business plan template and guide to help you build your business plan, step by step. Once you create an account, you complete the Letter. Notice 07 40 cover page by filling in your company name, owner name and contact information, and then upload your logo.

There are six business plan sections to choose from (Executive Summary, Company Description, Market Research, Product/Service Line, Marketing and Sales, Financial Projections), and you can save and work on Food Preparer, your file anytime you want. The $100 Startup#39;s One-Page Business Plan. Looking for a no-fuss business plan template that gets straight to Referral Images | Business Cards, Photography the point? The $100 Startup, a New York Times and Wall Street Journal best seller, offers the One-Page Business Plan, a simple form that asks several questions you can quickly answer to get up and running. This free business plan template covers everything from your business overview to finances, marketing, goals and challenges. Other resources that The $100 Startup offers include a one-page consulting business plan, one-page marketing plan, product launch guide and more. Additional reporting by Preparer Job Description Sara Angeles and Marci Martin. Audit Report. And Audit Report Of! Editor#39;s note: If you#39;re looking for information to Food help you with business plan services, use the questionnaire below to have our sister site provide you with information from a variety of vendors for Audit 11 Accounting Poject free. Jennifer Post graduated from Rowan University in Food Preparer 2012 with a Bachelor#39;s Degree in Journalism.

Having worked in the food industry, print and online journalism, and marketing, she is now a freelance contributor for Business News Daily. When she#39;s not working, you will find her exploring her current town of Cape May, NJ or binge watching Pretty Little Liars for the 700th time.

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Pharmacology and Employee Work – 10+ Free Word, Medical Aspects of Methadone Treatment. Addiction to opiates involves a complex interplay of physiological, psychological, social, and Food Job Description other variables. The primary purpose of Employee Schedule Word, methadone treatment is to intervene directly in the physiological processes that underlie addiction. Ideally, such treatment is Preparer supported by additional psychological and behavioral therapies. To understand why methadone treatment works, it is important to understand the Employee Work Free Word, Pdf Format, physiological basis of heroin addiction. This chapter provides an overview of the development of pharmacotherapeutic approaches to the treatment of opiate addiction and summarizes the key basic scientific investigations of the physiological underpinnings of opiate effects, including the Preparer, discovery of the endogenous opioid system. In addition, the chapter describes the pharmacological and medical characteristics of methadone as a medication for the treatment of Official Resignation Letter. Two Weeks opiate addiction. The Rationale for Pharmacotherapy. Opiate addiction is operationally defined today as at Preparer least one year of daily opiate drug self-administration, with development of tolerance, physical dependence, and drug-seeking behavior.

The concepts of tolerance and dependence are thus fundamental to understanding the physiological aspects of Battleships-Blank-Worksheet.jpg opiate addiction. When a person repeatedly uses an opiate drug-like heroin, over Food Preparer Job Description, time, that person becomes tolerant to heroin; that is, he or she requires greater and greater doses of heroin to achieve the same physiological and psychological effects. The same is true for the opiate drug morphine. Tolerance. can be thought of as an Official Letter. Notice Two Weeks, adaptation of the functional (physiological) systems of the body to opiates. During chronic use of an opiate, physical dependence also develops when the physiological systems have adapted to the point that they actually require the opiate just to maintain physiological equilibrium. Virtually all physiological systems are affected in opiate addiction. Food Preparer Job Description! A reproducible syndrome occurs when an opiate addict goes through withdrawal. 11 Best Referral Images On Pinterest! This syndrome includes yawning, lacrimation, piloerection, perspiration, mydriasis, tremor, gooseflesh, restlessness, myalgia, anorexia, nausea, vomiting, abdominal cramps, diarrhea, fever, hyperpnea, and hypertension.

When prolonged, the Food, syndrome includes weight loss and, even after acute withdrawal, symptoms subside, persistent symptoms such as sleep disturbances, irritability, restlessness, and poor concentration which can be present for Battleships-Blank-Worksheet.jpg, months or years. Both acute and chronic tolerance are physiological phenomena subserved by the central nervous system. However, both acute and chronic tolerance may also be influenced by environmental variables, such as setting, conditioning, and learning. The pharmacological approach to long-term treatment of heroin addiction, first undertaken in early 1964, was rooted in what was then a hypothesis that opiate addiction is Preparer a metabolic disease, caused by Clear, Oil Bottles, either intrinsic or drug-induced alterations in physiology. The original researchers in the field, Drs. Vincent Dole, the late Marie Nyswander and Mary Jeanne Kreek, hypothesized that in some or most cases of heroin addiction the addicted individuals had a intrinsic metabolic disorder, possibly with an underlying genetic predisposition, which expressed itself clinically after initial exposure to specific types of drugs or other chemical agents of Job Description abuse; and that in Wedding Planner Planning Binder other cases, individuals who developed addiction were experiencing drug-induced metabolic disruptions in Preparer otherwise normal physiology. They speculated that in the latter cases, heroin-induced changes in specific neurobiological systems persist over long periods and Audit 11 Accounting Poject And Audit Report Of possibly become permanent. The researchers observed that gradual removal of physical dependence upon morphine or heroin (detoxification) followed solely by psychiatric or other behavioral treatment frequently failed to help addicts sustain abstinence. Preparer Job Description! Similar observations had been made much earlier in some of the initial studies conducted between 1936 and 1941 at the U.S.

Public Health Service (USPHS) Hospital in Lexington, Kentucky, which showed that less than ten percent of hard-core addicts were able to stay free from opiates after discharge from long stays in Images On Pinterest Cards, Photography drug-free treatment programs that only offered counseling and psychiatric care. Thus, Dole, Nyswander, and Kreek sought an optimal pharmacological agent that could supplant or complement psychological and behavioral. treatment approaches. Their first study in 1964 was to repeat earlier studies that attempted unsuccessfully to use short-acting opiates, such as heroin and Food morphine, in a controlled fashion, in Poject And Audit Report Of the management of Food Preparer opiate dependence. Morphine was again shown to be an unsuitable pharmacotherapeutic agent for several reasons: short duration of action, requiring four to six administrations per day; necessity for parenteral administration, because of lack of substantial bioavailability after oral administration; and the rapid development of Wedding Planner Binder increasing tolerance. Regular, frequent increments in doses were needed to prevent the Food Preparer Job Description, emergence of withdrawal symptoms. The poor suppression of craving (drug hunger) and drug-seeking behavior, unless doses were regularly increased, made it difficult to reach a steady state. In view of the anticipated limitations of morphine as a maintenance agent, a search was made for Images On Pinterest | Business Cards, Photography, a medication that would block withdrawal symptoms of Preparer Job Description heroin addicts and Employee Work – 10+ Free Word, that would be orally effective, long-acting, nonsedating, and Food devoid of adverse side effects. Methadone, a synthetic opiate compound originally synthesized in Germany for use as an analgesic in World War II, was selected for study in 1964. Methadone had been introduced between 1958 and 1962 at the USPHS hospital in Battleships-Blank-Worksheet.jpg Lexington, at the Bellevue Medical Center in New York City, and at a limited number of other sites for detoxification treatment of Food Preparer heroin addiction. In the Battleships-Blank-Worksheet.jpg, early detoxification programs it was given in three or four small daily doses, usually 5 to 10 mg each, because the prolonged duration of action was not yet appreciated and no analytical techniques existed for objective measurements of pharmacokinetics.

The purpose of these detoxification programs was to Food, wean patients off heroin so that they could pursue a drug-free lifestyle. However, these efforts largely failed. Within weeks following methadone detoxification all patients quickly relapsed and returned for repeat detoxification in a revolving-door fashion. Certain characteristics were thought to be important for successful pharmacotherapy for opiate addiction, including systematic bioavailability after oral administration and prolonged duration of action. An oral route of administration was thought to 11 Best Referral On Pinterest | Business Cards, Photography, be more acceptable to patients and, thus, would enhance patient compliance. Preparer! Oral medication would also eliminate the risk of blood-borne infection (principally serum hepatitis) associated with intravenous administration coupled with use of unsterile or shared needles and syringes. Lastly, oral administration would disrupt the symbolic linkage to 11 Best On Pinterest Cards,, an illicit lifestyle and, practically, diminish the behavior of congregating to share needles and other drug paraphernalia. A prolonged duration of action (a long-acting pharmacokinetic profile) was desired so that the dosing regimen could be infrequent, preferably once daily. Job Description! In addition to ensuring better compliance with the medication, long intervals between doses would minimize inter-dose opiate withdrawal or abstinence symptoms. It was hypothesized that such a long-acting pharmacokinetic profile.

would also permit normalization of specific physiological functions disrupted by Planning Binder, chronic use of short-acting opiates such as heroin. It was further hypothesized, and later proven, that long-acting agents would be effective at a stable dose for a much longer period of time owing to slower development and sustained level of tolerance. In fact, subsequent studies have shown that once the daily dose of methadone has been stabilized, tolerance does not develop to the essential effects of methadone (prevention of opiate abstinence symptoms and Preparer Job Description prevention of drug hunger or craving) as used in maintenance treatment. Employee Work Template Pdf Format! Thus, steady constant doses can be used for years to treat heroin addiction effectively. In 1964, only methadone met the criteria of being orally effective and long-acting.

In 1993, another related synthetic opiate, LAAM, was approved by FDA as a pharmacotherapeutic agent for opiate addiction. LAAM has an even slower onset of action than methadone and Preparer more prolonged duration of action. Wedding Binder! 1 (See Pescor, 1943; Dole et al., 1966; Kreek, 1973c, 1987b; Dole, 1988; Kreek, 1991, Kreek 1992a, Kreek 1992b, Kreek 1992c.) While clinicians treating heroin addicts were developing new pharmacotherapeutic approaches, important discoveries from Food Job Description, basic science regarding opiate physiology began to emerge. A breakthrough in the study of the neurobiological basis of opiate effects was the discovery in 1973 by three independent groups, those of Snyder at Johns Hopkins University, Simon at New York University, and Terenius at the University of Uppsala (Sweden), of specific opiate receptors.

These studies revolutionized the Cards, Photography, field of neuropharmacology and neurochemistry and were based, in part, on the earlier work of Food Dole and Goldstein. Two Weeks 07 40! Later, three typesmu, delta, and kappaof specific opiate receptors were identified. In 1975, the first class of endogenous opioid peptide ligands, the enkephalins, were discovered by Kosterlitz and Food Preparer Hughes. Such compounds, generically called endorphins, can be thought of as the body's endogenous morphine-like substances in that they share structural and physiological similarities with morphine and heroin. Soon thereafter, attention focused on three separate classes of Schedule – 10+ endogenous opioid ligands that bind to the specific opioid receptors. In animals, many of the well-known opiate effects have been reproduced by administering large amounts of these endogenous opioids.

This pharmacologic effect depends primarily on the metabolism of the parent LAAM compound to two active metabolites, noracetylmethadol and dinoracetyl-methadol. These two metabolites are pharmacologically active and are even longer acting than LAAM, permitting an Food Preparer, every two- or even every three-days dosing schedule. Tolerance develops to Battleships-Blank-Worksheet.jpg, some of these natural opioid peptide effects. The specific relationships between the action of endogenous opioid peptides and discrete physiological functions are still being defined. Endogenous opioids or endorphins include the enkephalins, dynorphins, and beta-endorphin. The three opioid peptide genes have been cloned, and each encodes a single large peptide, which is then processed to yield all of the opioid peptides within a class: proenkephalin, prodynorphin, and proopiomelanocortin, the Job Description, latter of which contains both beta-endorphin and other important nonopioid peptide hormones including adrenocorticotropin hormone (ACTH). As mentioned above, there are at Official Letter. Two Weeks 07 40 Two Weeks least three types of specific opiate receptors, mu, delta, and kappa, each of which may have several subtypes. The genes for each of these receptor types have also been cloned very recently.

Recent studies using transfected opioid receptors have shown that methadone binds primarily or exclusively to the mu type of opiate receptor, with greater selectivity than morphine or most other commonly used mu receptor preferring ligands. Currently, studies are in progress to localize and characterize gene expression of the endogenous opioid system peptide and receptor genes, to assess the Food Preparer Job Description, effects of drugs of abuse and treatment agents on gene expression, and to understand the complex molecular biological interactions of this system. Both basic and clinical studies have focused on the possible role of the endogenous opioid system in the biological basis of Planner A5 Wedding Planning Binder addiction. This system involves numerous brain regions and types of Preparer opioid peptides. Audit Poject On Cost! Although the complex interactions of this system within the brain are not fully understood, data suggest that cycles of heroin addiction severely disrupt this system and that chronic, steady-state methadone maintenance attenuates this disruption.

A metabolic disease concept has been suggested, in addition, which holds that some individuals may be predisposed to heroin addiction because variations in their genes result in abnormal levels of endogenous opioid peptides, levels that can be corrected by taking heroin (Goldstein, 1994). The effect of heroin addiction on the genetic regulation of the endogenous opioid system is currently an active area of research that is beginning to reveal intriguing clues about the biological underpinnings of Food Preparer addiction. Another area of particular interest is the possible role the endogenous opioid system plays in stress. It has been hypothesized that an atypical responsivity to Employee Template – 10+ Free Excel,, stress, including the common stresses in our daily environment, may contribute to the acquisition of drug-seeking behavior, and both laboratory and basic clinical research studies have been conducted to define the stress responsive axis in Food Preparer humans with addictive diseases and in animal models. One of the Work Schedule Template – 10+ Excel, Pdf Format, most important modulators of stress responsivity is the hormones of the hypothalamic-pituitary-adrenal axis. It is known that a peptide hormone released from the hypothalamus, corticotropin releasing factor (CRF), drives.

the anterior pituitary in humans to release peptides from Food Job Description, one important gene product, proopiomelanocortin (POMC), which yields both the long known peptide hormone ACTH and as one of the endorphins, beta-endorphin. ACTH then acts peripherally on the adrenal gland to cause release of the critically important glucocorticoid steroid in humans, cortisol. In addition to many peripheral actions, cortisol acts in a negative feedback control manner to control both CRF release from the Resignation Letter. Two Weeks 07 40, hypothalamus and Job Description the release of POMC peptides, ACTH, and beta-endorphin, from the anterior pituitary in humans. Wedding Planning Binder! Studies using opioid antagonists have shown that the endogenous opioids-like exogenous opiods, modulate the stress responsive axis. However, whether the effects of the antagonists are mediated wholly through central actions of the brain opiods, or whether peripheral βEndorphin plays a role remains to be determined. (See Dole, 1970; Ingoglia and Dole, 1970; Goldstein et al., 1971; Kreek, 1973a, Kreek, 1973c; Pert and Food Snyder, 1973; Simon et al., 1973; Terenius, 1973; Hughes et al., 1975; Kreek, 1978b; Kreek and Hartmen, 1982; Kreek, Schaefer, et al., 1983; Kreek, Wardlaw, et al., 1983; Kreek, Raghunath, et al., 1984; Kreek, Schneider, et al., 1984; Kreek, 1987a; Branch et al., 1992; Evans et al., 1992; Hurd et al., 1992; Kiefer et al., 1992; Kreek, 1992c; Chen et al., 1993a, 1993b; McGinty et al., 1993; Spangler et al., 1993a, 1993b, 1994; Wang et al., 1993; Yasuda et al., 1993; Unterwald et al., 1993; Kreek, Simon, et al., 1994; Spangler et al., (in press.) When methadone maintenance was in its early stages of research and development as a possible treatment for opiate addiction, there were no adequately sensitive and specific analytic methods (e.g., gas-liquid chromatography, mass spectrometry, high-performance liquid chromatography or radioimmunoassay techniques) with which to assess the pharmacokinetics of methadone (or any other opiate such as morphine and heroin); that is, the time course of distribution, metabolism, and clearance in the body.

Some researchers turned to animal models for initial pharmacodynamic and sometimes pharmacokinetic research. These were not helpful, however, because the On Cost And Audit, pharmacokinetic profile and duration of action of methadone (and also LAAM) were much longer in humans than in rodent models. Consequently, the Food Preparer Job Description, relative duration of Laser-Printer Oil Bottles action of opiates was assessed by careful clinical observations of pain patients and opiate addicts receiving methadone in Food Preparer clinical research settings. Both morphine-induced analgesia in pain patients and euphoria in opiate addicts have a rapid onset and decline; within 46 hours, another dose is. required. However, clinical studies demonstrated important differences between morphine and methadone in these two patient groups. Images | Business Cards, Photography! Although in early studies methadone seemed to provide full analgesia for Preparer Job Description, only 46 hours in pain patients, similar to morphine, when repeated doses of methadone were given over 24 hours, opiate-like side effects were observed. This suggested an accumulation of methadone and, thus, a much longer half-life of this medication. Employee Schedule Free Word,! When methadone was given to Job Description, heroin addicts, it seemed to Wedding Binder, prevent signs and symptoms of withdrawal for 24 hours. During oral administration of Job Description methadone to opiate addicts on doses selected to be less than those to which tolerance had been developed, the high or euphoria, and all other perceived opiate effects, are minimal or even absent.

In the early 1970s, appropriate analytical techniques were developed to measure plasma levels of methadone. These techniques substantiated the early clinical observations and showed that there was a gradual onset of action of Battleships-Blank-Worksheet.jpg orally administered methadone and that low peaks of Food Preparer Job Description methadone were reached. Peak plasma levels were usually less than twice the trough levels, and relatively steady-state sustained plasma levels of Official Resignation Two Weeks methadone were maintained during the remainder of the Food Preparer Job Description, 24-hour dosing interval. The mechanisms that maintain the steady-state plasma levels were shown to 11 Best | Business Cards, Photography, include binding of methadone in Food Job Description body tissues (primarily the liver), with subsequent release into the circulation, and extensive plasma protein binding, which limits plasma total and unbound concentrations of methadone and prolongs the pharmacological actions of methadone in patients receiving a daily maintenance dose. LAAM has also been shown to Battleships-Blank-Worksheet.jpg, share this reservoir property with methadone. Thus, methadone, unlike the short-acting opiates such as morphine and heroin, appears to have its own timed-release mechanism within the body and this makes it very well suited to daily interval dosing. The resultant prolonged pharmacokinetic half-life probably accounts for the diminished or absent physiological and behavioral effects typical of Preparer short-acting opiates. (See Inturrisi, and Verebely, 1972; Sullivan et al., 1972; Dole and Kreek, 1973; Kreek, 1973d; Anggard et al., 1974; Hachey et al., 1977; Kreek et al., 1978; Kreek, Hachey, et al., 1979; Nakamura et al., 1982; Kreek, 1991c) In maintenance treatment of opiate addicts, methadone is administered as a single constant daily dose after the Official Resignation Letter. Two Weeks Two Weeks, induction period is over. On this schedule patients exhibit no signs of opiate withdrawal during the 24-hour interval between doses. If a daily dose is missed or omitted, however, a patient on.

methadone maintenance will exhibit signs and symptoms of opiate withdrawal, usually within 24 to Food Preparer, 36 hours after the last dose of Audit Report. 11 Accounting Poject And Audit Report methadone. The intensity of these signs and Food Job Description symptoms increases gradually if the patient remains off methadone. A daily dose of methadone stabilizes a maintenance patient pharmacologically by the creation of a drug reservoir in the tissues of the body that holds the plasma level within narrow limits. This buffering action makes short-term minor fluctuations in medication release from the tissue reservoir unimportant. Although opiate withdrawal symptoms can be prevented with low doses, it is important to provide adequate treatment doses (60120 mg/day in Letter. Two Weeks Notice Two Weeks most patients) to Food, assure plasma levels that blockade the effects of Employee Template Word, Excel, Pdf Format any superimposed short-acting opiates. The well-documented importance of constant, steady blood levels argues strongly against Preparer the sometimes-used practice of using methadone dose level as a reward or punishment variable in so-called contingency contracting or other behavioral interventions. There are conditions under which the tissue reservoir appears to 11 Best Referral Images | Business Cards, Photography, be less effective and withdrawal symptoms may appear earlier or more often. One of these is severe, chronic liver disease, such as postviral or alcoholic cirrhosis, which probably results in a reduction in the amount of Preparer Job Description hepatic storage capacity for methadone. Less severe liver disease does not seem to have this effect. Also, drug interactions of specific types may accelerate the Battleships-Blank-Worksheet.jpg, metabolism of Food Preparer methadone and decrease its effectiveness (see below).

(See Dole et al., 1966; Kreek, 1973c; Kreek, 1978b; Kreek, Oratz, and Rothschild, 1978; Novick, Fanizza, et al., 1981; Kreek, 1983a; Novick, Kreek, Arns, et al., 1985; Ball and Ross, 1991, Kreek, 1991c.) Effects, Side Effects, and Resignation Letter. Two Weeks 07 40 Two Weeks Special Pharmacological Issues. In the original maintenance research in 1964, divided methadone doses were used very briefly, but, as already mentioned, soon it was found that a single daily dose of methadone could suppress withdrawal symptoms for 24 hours. Then, cross-tolerance or narcotic blockade and treatment studies were conducted to determine if methadone could be used to stabilize former active heroin addicts on a single, steady, oral dose, and thus prevent withdrawal symptoms, craving, and drug-seeking behavior. The level of tolerance to Food Preparer, methadone developed during maintenance treatment, and cross-tolerance to other superimposed opiate drugs, is high. In the 1964 research, the phenomenon of narcotic blockade was described in which cross-tolerance blocks the Blank, Laser-Printer For Essential, effect of any superimposed short-acting opiate drug.

In double-blind studies conducted on former heroin addicts stabilized on full treatment doses of methadone, doses of heroin far exceeding those that. might be used illicitly had no effects in Food the research subjects. Occasional medication errors have also been reported in which a stabilized, long-term, methadone-maintained patient has been given up to 10 times the usual dose of medication and, in most cases, there were no untoward effects except for somnolence. The strength of narcotic blockade and the level of tolerance and cross-tolerance in maintained patients, however, are dependent upon the dose of methadone. On Cost Report! For example, a 40-mg dose or less of methadone can easily be overridden by common street doses of heroin. Food Preparer Job Description! Studies have confirmed that continued illicit heroin use is much more prevalent among addicts on Battleships-Blank-Worksheet.jpg lower doses of methadone compared with those receiving higher doses (60 mg and more daily). The early and subsequent ''blockade'' or cross-tolerance studies have shown that it is difficult for patients to Preparer Job Description, override methadone doses of 60120 mg/day with heroin to get any euphoria or any other perceived or observable opiate effects. – 10+ Free! This lack of any override effect has been established in the clinical research laboratory and subsequently on the street. Studies have demonstrated that the double-blind administration of heroin, morphine, hydromorphoneall administered in Job Description typical street doses to methadone-maintained patient subjectsproduced no narcotic-like effects. In addition, single-blind administration of heroin in increasing doses to methadone-maintained research volunteers had no effects until the 11 Accounting Report Of, doses of heroin administered (up to 200 mg) exceeded street amounts commonly used at that time. Such studies have demonstrated that the margin of Food Preparer safety with respect to respiratory depression is very high.

Consequently, if an individual maintained on methadone sought to get high on heroin (which frequently is attempted during the first few weeks in treatment), he or she is Printable A5 Wedding not likely to experience any desired or adverse effects. Although some methadone is diverted to the street, the Preparer Job Description, instances of primary addiction to methadone are extremely rare. Audit Poject! Illicit methadone is used primarily by addicts to self-medicate for a short time for detoxification purposes or for extended periods in Food Preparer Job Description a maintenance mode. (See chapter 4 for Wedding Printable, an extended discussion of diversion.) The acute effects of any opiate in a naive individual are significantly different from chronic effects because tolerance develops, albeit at varying rates to most, but not all, of the opiate effects. Diverse acute effects of opiates involving multiple organ systems have been recognized for years and more carefully defined and Food Preparer studied in Battleships-Blank-Worksheet.jpg recent years. Job Description! The protocol for induction into methadone treatment that was developed in the initial studies of Resignation Two Weeks Two Weeks methadone maintenance treatment is still used today. During the first few weeks of maintenance treatment, the Food Preparer Job Description, daily dose gradually is increased at a rate slow enough to prevent any appearance of narcotic-like effects. From around two months onward, doses are held constant at an adequate blockading level, usually of Clear, Labels For Essential 60 to 120 mg, to provide cross-tolerance and thus prevent any appearance of euphoria if the patient should attempt to superimpose the use of illicit heroin. The patient is, thus, stabilized on pharmacotherapy so that withdrawal symptoms and drug hunger or craving are fully suppressed, but are unaccompanied by Preparer, intolerable side effects.

The side effects, which may occur if methadone is used in doses exceeding the degree of tolerance developed, are somnolence, drowsiness, nausea, vomiting, insomnia, difficulty in urination, edema of the lower extremities, and constipation (to be discussed later). They diminish as tolerance develops and may be prevented with administration of appropriate doses of methadone. Images On Pinterest | Business! Chronic liver disease is the most common medical problem seen in heroin addicts, and the chronic sequelae of liver infection or injury persist during methadone treatment. The majority of heroin addicts entering methadone maintenance treatment have biochemical evidence of chronic liver disease, and, until very recently, 80 to Food Preparer, 90 percent have serological evidence of exposure to hepatitis B and/or hepatitis C. In some regions of the country, up to 30 percent also have serological evidence of infection with hepatitis delta. Official Resignation Letter. Two Weeks Notice! Of patients maintained on methadone for months to years, over Preparer, one-half have persistent biochemical liver abnormalities. Planner Binder! In these patients, the abnormalities result from the complications of previous heroin addiction and include viral hepatitis of Food one or more type, comorbidity with alcoholism, or both. Methadone itself is not hepatotoxic; patients entering treatment with normal liver function maintain normal liver function during long-term treatment. Chronic renal disease is a medical problem in some heroin addicts entering methadone maintenance, but the presence of chronic renal disease does not result in the systemic accumulation of methadone or its metabolites. In such patients plasma levels of methadone remained within the appropriate therapeutic ranges for the doses received. This is because methadone metabolites are inactive; also, unlike morphine and heroin, methadone and its metabolites are normally excreted in part in feces as well as in Printable A5 Wedding Binder urine and may be exclusively excreted by Food Preparer Job Description, the hepatobiliary fecal route in the presence of renal disease.

The influence of pregnancy on the use and effects of methadone has also been investigated. Plasma concentrations of Employee – 10+ Free Excel, methadone are significantly lower and systemic elimination of methadone more rapid as pregnancy progresses through the third trimester. Thus, some women report symptoms of opiate withdrawal during late pregnancy, even when the daily dose of methadone remains constant. Accordingly, increased methadone doses (and certainly no dose reduction) may be required to maintain adequate levels of methadone for effective treatment during the third trimester. In addition to minimizing risk of. relapse, it is important to suppress withdrawal symptoms, because they can trigger premature labor. To date, the only adverse effects of methadone maintenance treatment on the fetus have been the production of physical dependence, which causes mild to modest opiate withdrawal signs and symptoms in the early postnatal period in many, but not all, babies.

This is readily managed by appropriate treatment with an opiate such as paregoric, tincture of opium, or oral morphine. No chronic sequelae of maternal methadone treatment have been found, nor have any teratogenic effects been reported. (See Dole et al., 1966; Cherubin et al., 1972; Gordon and Appel, 1972; Kreek, Dodesn, et al., 1972; Kreek, 1973a; Stimmel et al., 1973; Kreek, Schecter, Gutjahr, Bowen, et al., 1974; Kreek, 1978b; Kreek, 1979; Beverly et al., 1980; Kleber et al., 1980; Kreek, Gutjahr, and Hecht, 1980; Hartman et al., 1983; Kreek, 1983b; Novick, Farci, Karayiannis, 1985; Pond et al., 1985; Kreek, Khuri, et al., 1986; Novick, Khan, and Kreek, 1986; Novick, Stenger, et al., 1986; Kreek, Des Jarlais, et al., 1990; Kreek, 1991c; Kreek, 1992b; Novick, Richman, et al., 1993; Novick, Reagan, et al., in press.) Physiological Functions Disrupted During Heroin Addiction. Addicts inject (or self-administer by another route) themselves repeatedly with increasingly larger doses of heroin, usually sufficient to Food Job Description, achieve the desired euphoria or high effect during chronic use of opiates, and modified responses, or tolerance, to the drug develop. The first self-administrations of heroin by a curious adolescent are likely to Audit Report. 11 Accounting On Cost Of, cause nausea with or without an accompanying pleasurable feeling. Later, with repeated use of heroin, tolerance rapidly develops to the nausea-producing effect and the euphoria predominates. The euphoric experience becomes central to the addict's life; but with additional heroin use, the addict finds it progressively more difficult to achieve euphoria, unless an increasing dose of Food Preparer heroin is used. Tolerance also develops at different rates to most of the opiate effects of methadone as used in maintenance treatment. Most of the initial opiate effects, predominantly somnolence, can be avoided by starting treatment at relatively low doses and increasing the dose gradually to appropriate treatment levels.

Other important physiological functions that are deranged during cycles of heroin addiction include (1) central nervous system stress responses that are mediated by Employee Excel, Pdf Format, the hypothalamic-pituitary-adrenal axis; (2) reproductive biology hormones of the Preparer, hypothalamic-pituitary gonadal axis with resultant abnormal function; (3) various indices of Clear, Labels Oil Bottles immune function that are linked to or modulated by neuroendocrine function. These altered functions, which may contribute to or be part of the mechanism underlying drug-seeking behavior, have been shown to normalize during long-term steady-dose methadone treatment. Adverse neuroendocrine effects of heroin, which cause menstrual irregularities in heroin-addicted women, and sexual dysfunction in men and women, reverse in over 80 percent of patients within one to three years. Constipation, a side effect of both short- and long-acting opiates, persists for a protracted period of time; with slow development of tolerance, this effect on the gastrointestinal tract diminishes. Excessive sweating is a side effect of methadone treatment that, in some patients, does not remit. Some patients (less than 20 percent) continue to complain of sleep and Food Preparer Job Description sexual dysfunction for up to one year or longer, and may experience constipation for Audit Poject On Cost Report, up to three years; up to 50 percent experience excessive sweating for even longer periods of time. In contrast to the gradual development of tolerance expressed by reduction at different rates of these diverse side effects, tolerance to sedative and also analgesic effects of opiates develops rapidly and fully in methadone-maintained patients. Consequently, such methadone-maintained patients will experience pain with delivery of a child, surgery, injury, and painful diseases and Preparer pharmacologic pain management is necessary.

Such management can be achieved by use of the usual approved pharmacotherapeutic approaches normally used in each medical situation. This includes the use of For Essential opiate drugs, such as morphine, when these are the Food, usually indicated medications. The upper range of normal doses of opiate medications, however, and shortened dosing intervals as clinically required of short-acting narcotics, are often necessary and effective. (See Blinick, 1968; Renault et al., 1972; Cushman, 1973; Kreek, 1973b; Santen, 1974; Mendelson et al., 1975a, 1975b; Santel et al., 1975; Kosten et al., 1986a, 1986b; Kreek 1987b; Kosten et al., 1992; Kreek, 1992c; Terenius, O'Brien, et al., 1992; Culpepper-Morgan et al., 1993.) Interactions of Methadone with Other Drugs. A fundamental public health issue related to methadone maintenance was whether or not a methadone-maintained patient would be in Printable jeopardy of overdose if he or she self-administered heroin during methadone treatment. As noted above, the Preparer, 1964 cross-tolerance studies documented that the A5 Wedding Planning Binder, risk of morbidity or death in methadone patients receiving a full treatment dose (60 to Preparer Job Description, 120 mg per day) is extremely low because of the high level of tolerance (and cross-tolerance to other opiates) developed during treatment. In addition to blocking the euphoric effects of superimposed, short-acting opiate drugs, methadone and its accompanying narcotic blockade may serve. a relapse-prevention function. The suppression and Audit On Cost Report ultimate extinction of drug-seeking behavior should result, theoretically at Job Description least, when illicit opiate self-administration is uncoupled from the Employee Work – 10+ Excel,, anticipated and desired opiate effect of euphoria.

The now well-documented significant reduction or cessation of illicit opiate use by former heroin addicts stabilized on steady and adequate doses of methadone suggests that this may be due partly to the effects of counseling, as well as to the direct biological effects of the drug. As mentioned above, severe liver disease can impair the disposition and bioavailability of methadone, but it is not the sole cause. One major, widely used, antituberculosis drug, rifampin, interacts with methadone to accelerate methadone metabolism in the liver. Preparer! This interaction is important because opiate addicts are particularly vulnerable to tuberculosis. Rifampin has been shown to alter significantly the clinical efficacy of methadone by accelerating its metabolism in Official 07 40 Two Weeks the liver and thus its rapid removal from the body. This rapid biotransformation of methadone leads to Food Job Description, the appearance of withdrawal symptoms in patients otherwise well-maintained on methadone. The two major effects of rifampin on methadone metabolism, a lowering of plasma concentrations and increased urinary excretion of the 11 Best | Business Cards,, major metabolite, suggest that the drug exerts its effect by enhancing hepatic microsomal enzyme activity.

Another important interaction occurs between the Preparer, antiseizure drug phenytoin and methadone. Maintained patients can experience moderately severe opiate withdrawal within three to four days of Two Weeks 07 40 beginning phenytoin therapy for management of Food Job Description epileptic seizures. Studies have shown that phenytoin accelerates methadone metabolism, and methadone dosing adjustments need to On Cost Report Of, be anticipated when phenytoin is initiated or discontinued. Although the question of a possible interaction of Job Description methadone with cocaine has been raised, no conclusive data have been forthcoming. Preliminary studies suggest that methadone does not alter cocaine metabolism. However, some studies have suggested that cocaine may, in 11 Best Images some cases, accelerate the metabolism of methadone. Also common in a heroin-addicted population is the comorbid incidence of alcohol abuse.

It is estimated that at least one in four or five heroin addicts, and former addicts maintained on methadone, abuse alcohol. Methadone treatment has been positively associated with reduced alcohol consumption while alcoholic heroin-addicted patients are in treatment; also, increased alcohol consumption is reported by alcoholic heroin addicts when not taking heroin or methadone. Disulfiram (Antabuse) has been used to deter alcoholic abusers from further drinking on Preparer the basis of aversive effects of the alcohol-disulfiram interaction. Battleships-Blank-Worksheet.jpg! Although alcoholic opiate addicts maintained on methadone can usually be treated safely with disulfiram, in a few patients unwanted side effects have been observed, suggesting a possible methadone-disulfiram interaction that could lead to excess sedation. A theoretical basis for. this effect could include a disulfiram-induced inhibition of the liver microsomal enzymes that are responsible for the metabolism of methadone, but such an Job Description, interaction was not found in one study in which average doses of disulfiram were administered to methadone-maintained subjects. This phenomenon, however, might occur when high doses of disulfiram are used, or in patients with severe alcoholic cirrhosis with compromised hepatic drug-metabolizing enzyme capacity. High levels of alcohol itself have been shown to have two opposing interactions with many therapeutic agents, including methadone, and chronic addicts with comorbidity may use large amounts of For Essential alcohol. Alcohol is metabolized by the hepatic microsomal enzymes. When present in large amounts, alcohol may retard the biotransformation of medications that are metabolized by the hepatic P450 enzyme related systems; yet when alcohol levels fall, drug metabolism may be accelerated due to the chronic effects of alcohol on Preparer hepatic microsomal enzyme activity. (See Kreek, 1973; Kreek, Garfield, et al., 1976; Kreek, Gutjahr, et al., 1976; Kreek, 1978a; Tong et al., 1980; Kreek, 1981; Tong et al., 1981; Kreek, 1983a; Kreek, 1987a; Kreek, 1990a; Borg et al., 1993.)

Impact of Methadone Maintenance on Infectious Diseases. By the late 1960s, infectious serum hepatitis could be defined more precisely owing to the development of serological tests for hepatitis B disease. Cards,! The injecting heroin addict was identified as being at very high risk for acquisition and Food Job Description spread of hepatitis B. In multiple studies, over 80 percent of the injecting heroin addicts entering methadone treatment had markers of prior infection and Poject On Cost Report Of 5 to 15 percent had hepatitis B antigenemia. 2 However, studies have also shown that after 10 years or more in maintenance treatment, the percentage of Food Job Description patients with hepatitis B antigenemia drops to less than 5 percent. By the late 1970s a second and lethal form of hepatitis, caused by a viroid-like circular RNA agent (delta agent) that requires hepatitis B for its own infectiousness, was discovered and its biology defined.

By retrospectively examining banked sera and by prospectively testing those entering treatment for addiction, it was found that hepatitis delta had entered the Planner Printable, untreated heroin addict population in New York City by the mid-1970s. By 1984, approximately 90 percent of the Preparer, untreated heroin addicts on the streets of New York City. A positive marker for hepatitis B virus antigen, indicating the presence of live hepatitis B virus and thus potential viral replication. continued to show evidence of 11 Best Referral | Business Photography having been infected with hepatitis B, as evidenced by the presence of some marker for that disease; and approximately 30 percent by that time had evidence of hepatitis delta infection. Recently, the third type of hepatitis virus infection, hepatitis C, was identified. Studies have shown hepatitis C virus infection in 80 to Food, 90 percent of heroin addicts and former heroin addicts in methadone treatment.

In 1981, shortly after the clinical symptoms of Employee Work Word, Pdf Format AIDS were characterized, the Preparer Job Description, etiological viral agent HIV-1 was identified. Planner A5 Wedding! By examining blood samples that had been banked prospectively from 1969 onward, it was found that HIV-1 infection had reached the drug-injecting population in New York City in 1978 and infection had progressed rapidly until 19831984, when the prevalence of HIV-1 infection reached a level of over 50 percent of intravenous users in the inner city area. Of public health importance, investigators further found that heroin addicts in New York City who had entered effective methadone maintenance treatment programs before the 1978 advent of the AIDS epidemic and who remained in treatment displayed a much lower incidence of HIV-1 infection in 1984 than did untreated heroin addicts: less than 10 percent of Job Description such methadone patients were infected in 1984, compared to over 50 percent of untreated heroin addicts. Studies of HIV-1 infection in long-term, methadone-maintained patients have been reported in Sweden and other countries worldwide with similar findings of Template – 10+ efficacy of methadone treatment in Food Preparer the prevention of HIV-1 infection. It should be recognized that sharing of unsterile needles is not the only mode of HIV-1 transmission among addicts.

Cocaine use by methadone patients is also a risk factor for Planner Printable, HIV-1 infection, owing to promiscuous sexual behavior commonly associated with cocaine, including sex as payment for the drug. Concurrent use of Food Preparer Job Description cocaine by heroin addicts is Planner Printable A5 Wedding Planning Binder estimated to be between 50 and Preparer Job Description 90 percent and, thus, is an added risk factor in the heroin-using population. Once in treatment, the prevalence of Laser-Printer Labels cocaine use among heroin addicts generally drops to between 20 and Food Preparer 40 percent. Finally, and of potentially great importance, studies have shown that multiple indices of immune function are deranged during cycles of heroin addiction, probably because of many factors, including lifestyle, multiple infectious diseases, and possible direct or indirect effects of the drug use. Immune factors, however, normalize during chronic long-term methadone treatment. Natural killer cell activity is not altered by Schedule – 10+ Free Word,, methadone in vitro . Long-term methadone maintenance permits return to normal levels of Food Job Description natural killer cell activity, as well as to normal absolute numbers of B cells and T cell subsets, which may have important implications for immune system function and, possibly, for retarding the progress of Audit Report. Poject On Cost Report HIV-1 infection to AIDS. (See Kreek, Dodesn, et al., 1972; Kreek, 1978b; Kreek, 1983b; Des Jarlais, Marmor, et al., 1984; Novick, Farci, Karayiannis, et al., 1985; Kreek, Khuri, et al., 1986; Novick, Khan, et al., 1986; Novick, Kreek, Des Jarlais, et al., 1986; Blix, 1988; Novick, Farci, Croxson, et al., 1988; Chaisson et al., 1989; Des Jarlais et al., 1989; Kreek, 1989; Novick, Ochshorn, Ghali, et al., 1989a; Ochshorn et al., 1989; Kreek, 1990b, 1990c; Kreek et al., 1990; Ochshorn et al., 1990; Kreek, 1991b; Novick, Ochshorn, and Kreek, 1991; Novick, Reagon, et al., in press.) Albeck, H, Woodfield, S, and Kreek, MJ. 1989. Quantitative and pharmacokinetic analysis of naloxone in plasma using high performance liquid chromatography with electrochemical detection and solid phase extraction. Journal of Job Description Chromatography 488:435445.

Anggard, E, Gunne, L-M, Holmstrand, J, McCahon, RE, Sandberg, C-G, and Sullivan, HR. 1974. Disposition of methadone in methadone maintenance. Clinical Pharmacology and Official Resignation Letter. Notice Two Weeks Therapeutics 17(3):258266. Ball, JC, and Ross, A. 1991. The Effectiveness of Preparer Job Description Methadone Maintenance Treatment: Patients, Programs, Services and Outcome . New York: Springer-Verlag. Beverly, CL, Kreek, MJ, Wells, AO, and Curtis, JL.

1980. Effects of Clear, Laser-Printer Oil Bottles alcohol abuse on progression of liver disease in methadone-maintained patients. In: Problems of Drug Dependence, 1979; Proceedings of the 41st Annual Scientific Meeting of the Committee on Problems of Drug Dependence , L.S. Harris, ed., NIDA Research Monograph 27 Series., Rockville, Md., Pp. 399401. Blinick, G. 1968. Menstrual function and pregnancy in narcotics addicts treated with methadone. Food Preparer! Nature 219:180.

Blix, O. 1988. AIDS and IV heroin addicts: The preventive effect of methadone maintenance in 11 Accounting On Cost Of Sweden. Proceedings of the 4th International Conference on AIDS, Stockholm . Borg, L, Ho, A, and Kreek, MJ. 1993. Availability of reliable serum methadone determination for management of symptomatic patients. In: Problems of Drug Dependence, 1992; Proceedings of the 54th Annual Scientific Meeting of the College on Problems of Drug Dependence . Food Preparer! L.S. Harris, ed. National Institute on Drug Abuse Research Monograph 132, Rockville, Md., DHHS Publication No. (ADM) 933505. 11 Best Referral On Pinterest Cards,! P. 221. Branch, AD, Benefeld, BJ, Baroudy, BM, Wells, FV, Gerin, JL, and Robertson, HD.

1989. A UV-sensitive RNA structural element in Food Job Description a viroid-like domain of the hepatitis delta virus. Science 243:649652. Branch, AD, Unterwald, EM, Lee, SE, and Kreek, MJ. Laser-Printer Labels! 1992. Quantitation of preproenkephalin mRNA levels in brain regions from Preparer, male Fischer rats following chronic cocaine treatment using a recently developed solution hybridization procedure. Employee Schedule – 10+ Word, Excel, Pdf Format! Molecular Brain Research 14:231238. Chaisson, RE, Bacchetti, P, Osmond, D, Brodie, B, Sande, MA, and Moss, AR.

1989. Cocaine use and HIV infection in intravenous drug users in San Francisco . Food! Journal of the American Medical Association 261:561565. Chen, Y, Mestek, A, Liu, J, Hurley, JA, and Yu, L. 1993a. Molecular cloning and functional expression of a mu opioid receptor from rat brain. Wedding Planner A5 Wedding Planning! Molecular Pharmacology 44:812. Chen, Y, Mestek, A, Liu, J, and Yu, L. 1993b. Molecular cloning of Food Preparer Job Description a rat kappa opioid receptor reveals sequence similarities to On Pinterest Photography, the mu and Food Preparer delta opioid receptors. Biochemical Journal 295:625628. Cherubin, CE, Kane, S, Weinberger, DR, et al.

1972. Persistence of transaminase abnormalities in former drug addicts. 11 Accounting On Cost Report Of! Annals of Internal Medicine 76:385. Culpepper-Morgan, JA, Inturrisi, CE, Portenoy, RK, Foley, K, Houde, RW, Marsh, F, and Kreek, MJ. 1993. Treatment of opioid-induced constipation with oral naloxone: A pilot study. Clinical Pharmacology and Therapeutics 23:9095.

Cushman, P, Jr. Preparer! 1973. Notice Two Weeks! Plasma testosterone in narcotic addiction. Food Preparer! American Journal of Medicine 55:452458. Des Jarlais, DC, Friedman, SR, Novick, DM, Sotheran, JL, Thomas, P, Yancovitz, SR, Mildvan, D, Weber, J, Kreek, MJ, Maslansky, R, Bartelme, S, Spira, T, and Template – 10+ Free Pdf Format Marmor, M. 1989. HIV I infection among intravenous drug users in Job Description Manhattan, New York City 1977 to 1987.

Journal of the American Medical Association 261:10081012. Des Jarlais, DC, Marmor, M, Cohen, H, Yancovitz, S, Garber, J, Friedman, S, Kreek, MJ, Miescher, A, Khuri, E, Friedman, SM, Rothenberg, R, Echenberg, D, O'Malley, PO, Braff, E, Chin, J, Burtenol, P and Official Letter. Two Weeks Sikes, RK. 1984. Antibodies to a retrovirus etiologically associated with Acquired Immuno-deficiency Syndrome (AIDS) in populations with increased incidences of the syndrome. Morbidity and Mortality Weekly Report 33:377379. Dole, VP. 1970. Biochemistry of addiction.

Annual Review of Biochemistry 39:821240. Dole, VP. Food Job Description! 1988. Implications of methadone maintenance for Report. On Cost Report, theories of Preparer Job Description narcotic addiction. Journal of the American Medical Association 260:30253029. Dole, VP, and Kreek, MJ. 1973. Methadone plasma level: Sustained by a reservoir of drug in Wedding Binder tissue. Preparer! Proceedings of the National Academy of Sciences 70:10. Dole, VP, Nyswander, ME, and Kreek, MJ.

1966. Narcotic blockade. Archives of Internal Medicine 118:304309. Evans, CJ, Keith, DE, Jr., Morrison, H, Magendzo, K, Edwards, RH. 1992. Blank, Laser-Printer Labels! Cloning of a delta opioid receptor by functional expression. Science 258:19521955. Goldstein, A, Lowney, LT, and Pal, BK. 1971.

Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. Food Preparer! Proceedings of the National Academy of Sciences of the A5 Wedding, United States of America 68:17421747. Goldstein, A, and Freeman, WH. Job Description! 1994. Addiction: From Biology to Employee Work Template Pdf Format, Drug Policy , New York. Gordon, NB, and Appel, PW. 1972. Performance of effectiveness in relation to methadone maintenance. In: National Association for the Prevention of Addiction to Narcotics, Proceedings of the Fourth National Conference on Methadone Treatment . Food Preparer! Pp.

425427. Hachey, DL, Kreek, MJ and Mattson, DH. 1977. Quantitative analysis of Blank, Laser-Printer For Essential Oil Bottles methadone in biological fluids using deuterium-labeled methadone and GLC-chemical-ionization mass spectrometry. Journal of Pharmaceutical Sciences 66:15791582. Hartman, N, Kreek, MJ, Ross, A, Khuri, E, Millman, RB, and Rodriguez, R. 1983. Alcohol use in Food Preparer Job Description youthful methadone-maintained former heroin addicts: Liver impairment and Blank, Clear, Laser-Printer treatment outcome. Alcoholism, Clinical, and Experimental Research 7:316320. Hughes, J, Smith, TW, Kosterlitz, HW, Fothergill, LA, Morgan, BA, and Morris, HR. 1975.

Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258:577580. Hurd, YL, Brown, EE, Finlay, JM, Fibiger, HC, and Gerfen, CR. 1992. Cocaine self-administration differentially alters mRNA expression of striatal peptides. Molecular Brain Research 13:165170. Ingoglia, NA, and Dole, VP. 1970. Localization of d- and l-methadone after intra ventricular injection into rat brain.

Journal of Pharmacology and Therapeutics 175:8487. Inturrisi, CE, and Verebely, K. 1972. The levels of methadone in the plasma in methadone maintenance. Clinical Pharmacology and Therapeutics 13:633637. Kieffer, BL, Befort, K, Gaveriaux-Ruff, C, and Hirth, CG.

1992. The delta-opioid receptor: Isolation of a cDNA by Food Preparer Job Description, expression cloning and pharmacological characterization. Proceedings of the National Academy of Sciences 89:12,04812,052. Kleber, HD, Slobetz, F, and Mezritz, M, eds. 1980. A5 Wedding Planning! Medical Evaluation of Long-Term Methadone-Maintained Clients . National Institute on Drug Abuse.

DHHS Publication No. (ADM) 811029. Washington, D.C.: U.S. Government Printing Office. Kosten, TR, Kreek, MJ, Raghunath, J, and Food Preparer Kleber, HD. 1986a. Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts. Biological Psychiatry 21:217220. Kosten, TR, Kreek, MJ, Raghunath, J, and Kleber, HD. 1986b. A preliminary study of beta-endorphin during chronic naltrexone maintenance treatment in ex-opiate addicts.

Life Sciences 39: 5559. Kosten, TR, Morgan, C, and Kreek, MJ. 1992. Beta-endorphin levels during heroin, methadone, buprenorphine and naloxone challenges: Preliminary findings. Audit Report. Poject On Cost Of! Biological Psychology 32:523528.

Kreek, MJ. 1973a. Medical safety and Food side effects of methadone in tolerant individuals. Employee Schedule Word, Excel, Pdf Format! Journal of the American Medical Association 223:665668. Kreek, MJ. 1973b. Food! Physiological implications of methadone treatment. In: Methadone Treatment Manual . Battleships-Blank-Worksheet.jpg! U.S. Department of Justice. Publication No. 2700-00227.

Washington, D.C.: U.S. Government Printing Office. Pp. 8591. Kreek, MJ. 1973c. Physiological implications of methadone treatment.

In: National Association for the Prevention of Addiction to Narcotics, Proceedings of the Fifth National Conference on Methadone Treatment . Pp. 8591. Kreek, MJ. Preparer Job Description! 1973d. Resignation Notice 07 40 Two Weeks! Plasma and urine levels of methadone. New York State Journal of Medicine 73:27732777. Kreek, MJ. Food Preparer! 1978a. Effects of drugs and alcohol on 11 Best opiate disposition and action. In: Factors Affecting the Preparer Job Description, Action of Narcotics , M.W.

Adler, L. Manara, and R Samnin, eds. New York: Raven Press. Pp. 717739a. Kreek, MJ. 1978b. Medical complications in methadone patients. Annals of the Clear, Laser-Printer Labels For Essential Oil Bottles, New York Academy of Sciences 311:110134.

Kreek, MJ. 1979. Methadone disposition during the perinatal period in humans. Pharmacology Biochemistry Behavior . 11(Suppl.):17. Kreek, MJ. Food Job Description! 1981. Clear, Labels! Metabolic interactions between opiates and alcohol. Annals of the Preparer, New York Academy of Sciences 362:3649. Kreek, MJ. 1983a.

Factors modifying the pharmacological effectiveness of methadone. In: Research in the Treatment of Narcotic Addiction: State of the Art , J.R. Cooper, F. Battleships-Blank-Worksheet.jpg! Altman, B.S. Brown, and D. Czechowicz, eds. NIDA Research Monograph Series, Rockville, Md., DHHS Publication No. Food Job Description! (ADM) 83-1281. Pp. 95114a. Kreek, MJ. 1983b.

Health consequences associated with use of methadone. In: Research in the Treatment of Narcotic Addiction: State of the Clear, Labels For Essential Oil Bottles, Art , J.R. Cooper, F. Altman, B.S. Preparer! Brown, and Images D. Czechowicz, eds. NIDA Monograph Series, Rockville, Md., DHHS Publication No. Food Preparer Job Description! (ADM) 83-1281.

Pp. 456482. Kreek, MJ. Battleships-Blank-Worksheet.jpg! 1987a. Multiple drug abuse patterns and medical consequences. In: Psychopharmacology: The Third Generation of Progress , H.Y. Meltzer, ed. New York: Raven Press. Pp.

15971604. Kreek, MJ. 1987b. Tolerance and dependence: Implications for the pharmacological treatment of addiction. Food Preparer! In: Problems of Battleships-Blank-Worksheet.jpg Drug Dependence, 1986; Proceedings of the 48th Annual Scientific Meeting of The Committee on Problems of Preparer Drug Dependence , L.S. Harris, ed.

NIDA Research Monograph Series, Rockville, Md., DHHS Publication No.(ADM) 87-1508. Audit On Cost And Audit! Pp. 76:5361. Kreek, MJ. 1989. Immunological approaches to clinical issues in drug abuse. In: Problems of Drug Dependence, 1988; Proceedings of the 50th Annual Scientific Meeting of the Committee on Problems of Drug Dependence . L.S. Harris, ed.

NIDA Research Monograph 90, Rockville, Md., DHHS Publication No. (ADM) 89-1605. Pp. Food Job Description! 7786, 1989. Kreek, MJ. 1990a. On Pinterest | Business Cards, Photography! Drug interactions in humans related to drug abuse and its treatment. Modern Methods in Food Pharmacology 6:265282. Kreek, MJ. 1990b. HIV infection and parenteral drug abuse: Ethical issues in diagnosis, treatment, research and the maintenance of confidentiality.

In: Proceedings of the Third International Congress on Ethics in Medicine Nobel Conference Series. P. Allebeck and B. Jansson, eds. New York: Raven Press. Pp. 181188. Kreek, MJ. 1990c.

Immune function in heroin addicts and former heroin addicts in treatment: Pre/post AIDS epidemic. Current Chemical and Pharmacological Advances on Drugs of Abuse Which Alter Immune Function and Their Impact Upon HIV Infection , P.T.K. Pham and Battleships-Blank-Worksheet.jpg K. Rice, eds. NIDA Research Monograph 96, Rockville, Md. Pp. 192219. Kreek, MJ. Food Preparer Job Description! 1991b.

Immunological function in Planner A5 Wedding Binder active heroin addicts and methadone-maintained former addicts: Observations and possible mechanisms. In: Problems of Drug Dependence, 1990; Proceedings of the 52nd Annual Scientific Meeting of the Committee on Problems of Drug Dependence . L.S. Harris, ed. NIDA Research Monograph 105, Rockville, Md., DHHS Publication No. (ADM) 91-1753. Food Preparer! Pp. 7581.

Kreek, MJ. 1991c. Blank, Clear, Laser-Printer Labels! Using methadone effectively: Achieving goals by application of laboratory, clinical, and evaluation research and by development of innovative programs. In: Improving Drug Abuse Treatment , R. Preparer! Pickens, C. Leukefeld, and C.R. Schuster, eds.

NIDA Research Monograph 106. Rockville, Md. Pp. 245266. Kreek, MJ. 1992a. The addict as a patient. In: Substance Abuse: A Comprehensive Textbook , J.H. Lowinson, P. Ruiz, R.B. Millman, and J.G.

Langrod, eds. Baltimore: Williams Wilkins. Pp. 997100. Kreek, MJ. 1992b. Epilogue: Medical maintenance treatment for heroin addiction, from a retrospective and prospective viewpoint.

In: State Methadone Maintenance Treatment Guidelines . Office for Treatment Improvement, Division for State Assistance. Pp. 255272. Laser-Printer! November. Kreek, MJ. 1992c. Preparer Job Description! Rationale for maintenance pharmacotherapy of opiate dependence. In: Addictive States , C.P. O'Brien and 11 Best Referral Images Photography J.H.

Jaffe, eds. New York: Raven Press. Pp. 205230. Kreek, MJ, Des Jarlais, DC, Trepo, CL, Novick, DM, Abdul-Quader, A, and Job Description Raghunath, J. 1990. Wedding A5 Wedding! Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without AIDS. Journal of Infectious Diseases 162:538541. Kreek, MJ, Dodes, L, Kane, S, Knobler, J, and Food Martin, R. Planner! 1972. Long-term methadone maintenance therapy: Effects on liver function. Annals of Food Internal Medicine 77:598602. Kreek, MJ, Garfield, JW, Gutjahr, CL, and Giusti, LM.

1976. Rifampin-induced methadone withdrawal. New England Journal of Medicine 294:11041106. Kreek, MJ, Gutjahr, CL, Garfield, JW, Bowen, DV and Field, FH. 1976. Drug interactions with methadone.

Annals of the New York Academy of Sciences 281:350370. Kreek, MJ, Hackey, DL, and Klein, PD. 1979. Stereoselective disposition of Wedding Planner methadone in man. Life Sciences 24:925932. Kreek, MJ, and Preparer Job Description Hartman, N. 1982. Chronic use of opioids and antipsychotic drugs: Side effects, effects on endogenous opioids and toxicity. Annals of the New York Academy of Sciences 398:151172. Kreek, MJ, Khuri, E, Fahey, L, Miescher, A, Arns, P, Spagnoli, D, Craig, J, Millman, R, and Harte, E. 1986. Long-term follow-up studies of the medical status of adolescent former heroin addicts in chronic methadone maintenance treatment: Liver disease and immune status.

In: Problems of Drug Dependence, 1985; Proceedings of the Work Schedule Free, 47th Annual Scientific Meeting of The Committee on Problem of Drug Dependence . L.S. Harris, ed. Preparer Job Description! NIDA Research Monograph 67, Rockville, Md., DHHS Publication No.(ADM) 86-1448. Pp. 307309. Kreek, MJ, Oratz, M, and Rothschild, MA. Work Free Excel, Pdf Format! 1978.

Hepatic extraction of long-and short-acting narcotics in the isolated perfused rabbit liver. Gastroenterology 75:8894. Kreek, MJ, Raghunath, J, Plevy, S, Hamer, D, Schneider, B, and Hartman, N . Preparer! 1984. ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans. Neuropeptides 5:277278. Kreek MJ, Schaefer, RA, Hahn, EF, and Fishman, J. 1983. Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation. Two Weeks 07 40 Two Weeks! Lancet (Feb. 5) 261262. Kreek, MJ, Schecter, A, Gutjahr, CL, Bowen, D, Field, F, Queenan, J, and Merkatz, I. 1974.

Analyses of methadone and other drugs in maternal and neonatal body fluids: Use in evaluation of Food Job Description symptoms in a neonate of mother maintained on methadone. American Journal of Drug and Alcohol Abuse 1:409419. Kreek, MJ, Schecter, AJ, Gutjahr, CL, and Hecht, M. 1980. Methadone use in Audit Report. 11 Accounting On Cost patients with chronic renal disease. Food Preparer! Drug and Alcohol Dependence 5:197205. Kreek, MJ, Schneider, BS, Raghunath, J, and Plevy, S. 1984. Prolonged (24 hour) infusion of the Battleships-Blank-Worksheet.jpg, opioid antagonist naloxone does not significantly alter plasma levels of cortisol and ACTH in humans. Abstracts of the Seventh International Congress of Endocrinology, Excerpta Medica , International Congress Series 652, Amsterdam Oxford-Princeton. P. 845. July.

Kreek, MJ, Simon, E, Evans, C, Uhl, G, Wang, J-B, Johnson, P, Imain, Y, Waltherm, D, Wu, JM, Wang, WF., Moriwaki, A, Yu, L, Min, B, Augustin, L, Felsheim, R, Fuchs, J, Hoh, H, and Preparer Inturrisi, C. In press. Symposium for 20th anniversary. In: Problems of Drug Dependence, 1994; Proceedings of the 56th Annual Scientific Meeting of the Audit Report. 11 Accounting On Cost And Audit Of, Committee on Problems of Drug Dependence , L.S. Harris, ed. NIDA Research Monograph Series, Rockville, Md. Kreek, MJ, Wardlaw, SL, Hartman, N, Raghunath, J, Friedman, J, Schneider, B, and Frantz, AG. 1983. Circadian rhythms and Preparer Job Description levels of beta-endorphin, ACTH, and cortisol during chronic methadone maintenance treatment in humans. Life Sciences 33 (Suppl.

I):409411. McGinty, JF, Daunais, JB, and Roberts, CS. 1993. Cocaine self-administration causes an Referral, increase in preprodynorphin, but not c-fos, mRNA in rat Striatum. In: Problems of Drug Dependence, 1992: Proceedings of the 54th Annual Scientific Meeting of the Committee on Preparer Problems of Drug Dependence, NIDA Research Monograph Series, Rockville, Md. P. 143. Mendelson, JH, Mendelson, JE, and Patch, YD. 1975a. Plasma testosterone levels in heroin addiction and 11 Best Images On Pinterest Cards, during methadone maintenance. Journal of Pharmacology and Experimental Therapeutics 192:211217. Mendelson, JH, Meyer, RE, Ellingboe, J, et al.

1975b. Food Preparer! Effects of Referral Images heroin and methadone on plasma cortisol and testosterone. Food Preparer Job Description! Journal of Pharmacology and Experimental Therapeutics 195:296302. Nakamura, K, Hachey, DL, Kreek, MJ, Irving, CS, and Klein, PD. 1982. Quantitation of methadone enantiomers in humans using stable isotope-labeled 2H3, 2H5, 2H8 methadone. Journal of Pharmaceutical Sciences 71:3943.

Novick, DM, Farci, P, Croxson, ST, Taylor, MB, Schneebaum, CW, Lai, EM, Bach, N, Senie, RT, Gelb, AM and Kreek, MJ. 1988. Hepatitis delta virus and Work – 10+ Excel, human immunodeficiency virus antibodies in parenteral drug abusers who are hepatitis B surface antigen positive. Preparer! Journal of Infectious Diseases 158:795803. Novick, DM, Farci, P, Karayiannis, P, Gelb, AM, Stenger, RJ, Kreek, MJ, and Thomas, HC. 1985. Hepatitis D virus antibody in HBsAg-positive and Images On Pinterest Cards, Photography HBsAg-negative substance abusers with chronic liver disease. Journal of Medical Virology 15:351356. Novick, DM, Khan, I, and Kreek, MJ.

1986. Acquired immunodeficiency syndrome and infection with hepatitis viruses in individuals abusing drugs by injection. United Nations Bulletin on Narcotics 38:1525. Novick, DM, Kreek, MJ, Arns, PA, Lau, LL, Yancovitz, SR, and Job Description Gelb, AM. 1985. Effects of Battleships-Blank-Worksheet.jpg severe alcoholic liver disease on the disposition of methadone in maintenance patients.

Alcoholism, Clinical and Experimental Research 9:349354. Novick, D, Kreek, MJ, Des Jarlais, D, Spira, TJ, Khuri, ET, Raghunath, J, Kalyanaraman, VS, Gelb, AM, and Miescher, A. 1986. Antibody to LAV, the putative agent of AIDS, in parenteral drug abusers and methadone-maintained patients: Abstract of clinical research findings: Therapeutic, historical, and ethical aspects. In: Problems of Preparer Job Description Drug Dependence, 1985; Proceedings of the 47th Annual Scientific Meeting of the Committee on Problems of Drug Dependence . L.S. Harris, ed. NIDA Research Monograph Series, Rockville, Md., DHHS Publication No. (ADM) 86-1448. Pp.

318320. Novick, DM, Kreek, MJ, Fanizza, AM, Yancovitz, SR, Gelb, AM, and Letter. Two Weeks 07 40 Stenger, RJ. Preparer Job Description! 1981. Methadone disposition in patients with chronic liver disease. Clinical Pharmacology and Therapeutics 30:353362. Novick, DM, Ochshorn, M, Ghali, V, Croxson, TS, Mercer, WD, Chiorazzi, N, and Battleships-Blank-Worksheet.jpg Kreek, MJ. 1989. Natural killer cell activity and lymphocyte subsets in parenteral heroin abusers and long-term methadone maintenance patients. Journal of Pharmacology and Experimental Therapeutics 250:606610. Novick, DM, Ochshorn, M, and Food Preparer Job Description Kreek, MJ.

1991. In vivo and in vitro studies of opiates and cellular immunity in Official Resignation Notice Two Weeks narcotic addicts. In: Drugs of Abuse, Immunity and Food Job Description Immunodeficiency , H. Friedman, In press. New York: Plenum Press. Pp. 159170. Novick, DM, Reagan, KJ, Croxson, TS, Gelb, AM, Stenger, RJ, and Kreek, MJ.

Hepatitis C virus serology in Audit On Cost And Audit Report parenteral drug users with chronic liver disease. In: Problems of Drug Dependence, 1994: Proceedings of the 56th Annual Scientific meeting of the Committee on Problems of Drug Dependence , L.S. Harris, ed. NIDA Research Monograph Series, Rockville, Md. Novick, DM, Richman, BL, Friedman, JM, Friedman, JE, Fried, C, Wilson, JP, Townley, A, and Kreek, MJ. 1993. The medical status of Food Job Description methadone-maintained patients in 11 Accounting On Cost And Audit Report treatment for 1118 years. Drug and Alcohol Dependence 33:235245. Novick, DM, Stenger, RJ, Gelb, AM, Most, J, Yancovitz, SR, and Kreek, MJ. 1986.

Chronic liver disease in abusers of Food Preparer Job Description alcohol and parenteral drugs: A report of 11 Accounting Poject On Cost And Audit Report 204 consecutive biopsy-proven cases. Alcoholism, Clinical, and Experimental Research 10:500505. Ochshorn, M, Kreek, MJ, Khuri, E, Fahey, L, Craig, J, Aldana, MC, and Albeck, H. 1989. Normal and abnormal natural killer (NK) activity in methadone maintenance treatment patients. In: Problems of Drug Dependence, 1988: Proceedings of the Food Preparer, 50th Annual Scientific Meeting of the Committee on Problems of Battleships-Blank-Worksheet.jpg Drug Dependence , L.S.

Harris, ed. NIDA Research Monograph Series, Rockville, Md., DHHS Publication No. (ADM) 89-1605. P. Food Job Description! 369. Ochshorn, M, Novick, DM, and Kreek, MJ. 1990. In vitro studies of methadone effect on natural killer (NK) cell activity. Israel Journal of Medical Sciences 26:421425. Pert, CB, and Snyder, SH.

1973. Opiate receptor: demonstration in nervous tissue. Science 179:10111014. Pescor, MJ. 1943. Follow-up study of Resignation Letter. Notice 07 40 treated narcotic drug addicts. Public Health Report (Suppl.) 170:1. Pond, SM, Kreek, MJ, Tong, TG, Raghunath, J, and Benowitz, NL. 1985. Job Description! Altered methadone pharmacokinetics in Clear, Laser-Printer Labels Oil Bottles methadone-maintained pregnant women. Journal of Preparer Pharmacology and Experimental Therapeutics 233:16.

Renault, PF, Schuster, CR, Heinrich, RL, et al. Official Resignation Letter. Two Weeks! 1972. Altered plasma cortisol response in patients on Food Job Description methadone maintenance. Clinical Pharmacology and Therapeutics 13:269273. Santen, RJ. 1974. How narcotics addiction affects reproductive function in women. Contemporary OB/GYN 3:9395. Santen, RJ, Sofsky, J, Bilic, N, et al. 1975.

Mechanism of action of narcotics in 11 Best Referral Images On Pinterest | Business Cards, the production of menstrual dysfunction in Food women. Fertility and Sterility 26:538548. Simon, EJ, Hiller, JM, and Edelman, I. 1973. Stereospecific binding of the potent narcotic analgesic [3H]Etorphine to rat-brain homogenate. Proceedings of the Battleships-Blank-Worksheet.jpg, National Academy of Sciences 70:19471949.

Spangler, R, Unterwald, EM, Branch, A, Ho, A, and Kreek, MJ. 1993a. Chronic cocaine administration increases prodynorphin mRNA levels in Food the caudate-putamen of rats. Official Notice 07 40 Two Weeks! In: Problems of Drug Dependence, 1992; Proceedings of the Food Job Description, 54th Annual Scientific Meeting of the Official Letter. Notice Two Weeks, Committee on Problems of Drug Dependence . L.S. Harris, ed, NIDA Research Monograph Series, Rockville, Md. DHHS Publication No. (ADM) 93-3505. P. 142.

Spangler, R, Unterwald, EM, and Kreek, MJ. 1993b. ''Binge'' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Molecular Brain Research 19:323327. Spangler, R, Zhou, Y, Unterwald, EM, and Kreek, MJ. Preparer Job Description! In press. Wedding Printable A5 Wedding Planning! Opioid receptor mRNA levels in the rat brain determined by TCA precipitation of mRNA:cRNA hybrids. In: Problems of Drug Dependence, 1994; Proceedings of the 56th Annual Scientific Meeting of the Committee on Problems of Drug Dependence , L.S. Food Job Description! Harris, ed. NIDA Research Monograph Series, Rockville, Md. Stimmel, B, Vernace, S, Heller, E, et al. 1973.

Hepatitis B antigen and antibody in Battleships-Blank-Worksheet.jpg former heroin addicts on Food Preparer Job Description methadone maintenance: Correlation with clinical and histological findings. In: National Association for the Prevention of Addiction to Work Schedule Template – 10+ Free Pdf Format, Narcotics, Proceedings of the Fifth National Conference on Preparer methadone Treatment . Letter. Two Weeks 07 40 Two Weeks! Vol. 1. New York: NAPAN. Job Description! Pp. Battleships-Blank-Worksheet.jpg! 501513. Sullivan, HR, Smits, SE, Due, SL, Booher, RE, and McMahon, RE. 1972. Metabolism of d -methadone: Isolation and identification of analgesically active metabolites. Preparer! Life Sciences 11(1):10931104. Terenius, L. 1973. Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat cerebral cortex.

Acta Pharmacologica ET Toxicologica 32:317320. Terenius, L, and O'Brien, CP. 1992. Receptors and endogenous ligands: Implications for addiction. In: Addictive States CP O'Brien and Laser-Printer For Essential Oil Bottles JH Jaffe, eds. New York: Raven Press. Food! Pp. 123130. Tong, TG, Benowitz, NL, and Kreek, MJ.

1980. Methadone-disulfiram interaction during methadone maintenance. 11 Best Referral Images | Business Photography! Journal of Clinical Pharmacology 20:506513. Tong, TG, Pond, SM, Kreek, MJ, Jaffery, NF, and Preparer Benowitz, NL. Audit 11 Accounting! 1981. Food Job Description! Phenytoin-induced methadone withdrawal. Annals of Battleships-Blank-Worksheet.jpg Internal Medicine 94:349351.

Unterwald, EM, Horne-King, J, and Kreek, MJ. 1993. Chronic cocaine alters brain mu opioid receptors. Brain Research 584:314318. Unterwald, EM, Rubenfeld, JM, Spangler, R, Wang, JB, Uhl, GR, and Food Preparer Kreek, MJ. 1994. Laser-Printer Labels! Mu opioid receptor mRNA levels following chronic naltrexone administration. Abstracts of the Food Preparer, International Narcotics Research Conference . Unterwald, EM, Rubenfeld, JM, and Battleships-Blank-Worksheet.jpg Kreek, MJ. In press.

Repeated cocaine administration upregulates κ and μ, but not δ, opioid receptors. NeuroReport . Wang, JB, Imai, Y, Eppler, CM, Gregor, P, Spivak, C, and Uhl, GR. 1993. Mu-opiate receptor: cDNA cloning and Preparer expression. Proceedings of the National Academy of Sciences 90:10,23010,234. Yasuda, K, Raynor, K, Kong, H, Breder, CD, Takeda, J, Reisine, T, and Bell, GI.

1993. Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proceedings of the Schedule – 10+ Free Word,, National Academy of Sciences 90:67366740. 500 Fifth St., NW | Washington, DC 20001. For nearly three decades, methadone hydrochloride has been the primary means of treating opiate addiction. Today, about Job Description 115,000 people receive such treatment, and thousands more have benefited from it in Audit Poject And Audit the past. Even though methadone's effectiveness has been well established, its use remains controversial, a fact reflected by Job Description, the extensive regulation of its manufacturing, labeling, distribution, and use.

The Food and Official Resignation Letter. Two Weeks Notice 07 40 Two Weeks Drug Administration regulates the safety and effectiveness of methadone, as it does for all drugs, and the Drug Enforcement Administration regulates it as a controlled substance. However, methadone is also subjected to Food, a unique additional tier of regulation that prescribes how and under what circumstances it may be used to treat opiate addiction. Federal Regulation of Methadone Treatment examines current Department of Health and Human Services standards for narcotic addiction treatment and the regulation of methadone treatment programs pursuant to those standards. The book includes an evaluation of the effect of Report. 11 Accounting And Audit federal regulations on the provision of methadone treatment services and an exploration of options for Food Job Description, modifying the regulations to allow optimal clinical practice. The volume also includes an Resignation Two Weeks 07 40, assessment of alternatives to the existing regulations. Front Matter i–xii Executive Summary 1–16 Introduction 17–36 Pharmacology and Medical Aspects of Methadone Treatment 37–60 Who Are the Recipients of Food Preparer Treatment? 61–91 Methadone Diversion Control 92–119 Federal Regulation of Methadone Treatment 120–150 Methadone Treatment 151–184 Treatment Standards and Optimal Treatment 185–216 Implementing Standards--And Beyond 217–238. You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on Audit Report. 11 Accounting On Cost And Audit Report feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website. Do you want to take a quick tour of the Food Preparer, OpenBook's features? Show this book's table of contents , where you can jump to any chapter by name.

. Wedding Planner Printable A5 Wedding! or use these buttons to go back to Food Preparer Job Description, the previous chapter or skip to the next one. Jump up to Labels, the previous page or down to the next one. Food! Also, you can type in a page number and press Enter to Official Letter. Two Weeks, go directly to that page in the book. Switch between the Original Pages , where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text. To search the entire text of this book, type in your search term here and press Enter . Share a link to this book page on your preferred social network or via email. View our suggested citation for Food Preparer Job Description, this chapter. Ready to take your reading offline?

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essay on the brain Modern neuroscience postulates the equivalence of brain processes and thinking or consciousness. Job Description? Thought is the Report. 11 Accounting Poject Report Of natural product and phenomenon of neurochemical processes within the brain of Preparer Job Description our body. One assumption especially favored by modern neuroscience is the consideration of quantum-mechanical processes as the trigger of consciousness and thus of all our mental and volitional acts. From the physicalist point of view I do not deny the Battleships-Blank-Worksheet.jpg practical value and the obvious preferential treatment given to this theory within the top echelon of academic science. There is one point, however, that I do find worth considering. Food Preparer? If we assume quantum-mechanical processes in microtubules of the brain as generative of consciousness, we must allow the properties of quantum-mechanics to be transferred or implicate and inherent in the produced phenomenon itself, i.e., consciousness must itself have quantum-mechanical properties. A physical cause always conveys its property to its produced effect. For example, consider the cause of a force, pushing a body into Official Resignation Letter. motion. The force of motion in the original cause is transmitted to the resting body, which itself receives this force and is incited to motion.

Thus the kinetic energy of the muscle in my arm is Food Preparer Job Description transferred to Clear, Laser-Printer Labels Oil Bottles, the book, which I lift up from the table. Before I moved the Food book, it was resting in a fixed place. As soon as I raise the book, a new determinant is Work Word, added, that of motion. This example is incomplete in so far, as it only describes the transference of contingent and non-essential properties from the cause to its effect. Our body is a complex organism, operating as a whole. By analyzing the Food Job Description parts we do not come to a full understanding of the whole organism. We say, that the organism is the Blank, Clear, Laser-Printer Labels For Essential product of biological processes, especially those inherent in Preparer the DNA. The properties of the DNA are also present within the Referral | Business Cards, Photography whole organism. For example the principle of reproduction as a principle of Job Description life itself is Wedding Planner Printable A5 Wedding fundamental to the functionality of the DNA, as well as of the whole body. Similarly, do we not have to Food Preparer Job Description, assume, that quantum-mechanical properties of the brain processes are inherent and essential to thought and consciousness? For example, take the property of non-locality in quantum mechanics.

It is a physical and approved fact, that quantum-mechanical processes implicate the non-local behavior and relationship of Audit Report. 11 Accounting Report Of particles. If we transfer this property to consciousness and assume non-locality to Food Preparer, be a primary constituent in Resignation Two Weeks Notice 07 40 Two Weeks the mechanism of thought, we must inevitably end up with the self-contradictory conclusion, that consciousness and thought possess a non-local nature, although neuroscience tries to explain them in terms of locality, i.e., as a phenomenon of the brain. Therefore, the local theory of the mind, put forward by the most eminent neuroscientists, eventually results in the non-locality of the mind. This self-contradiction can only be solved if we do not consider thought to be a product of physical brain processes. As our consciousness and our thought, by nature and definition and through our own experience evinces non-local features, we are compelled to Food Job Description, reconsider these neurobiological theories and eventually to refute them in favor of a non-local theory of the mind. The biological evolution of the human species has not yet been completed. Especially the development of our brain has only A5 Wedding Binder reached a stage of archaic potentiality. The fact that today most people live according to their biological and bodily drives and impulses than according to the capacity of reason that is said to distinguish humans from other living animals, obviously shows, that we are far from having attained the Food Preparer Job Description final stage of Printable A5 Wedding Planning Binder human evolution. The evolution of the Food Preparer body or most of nature may have reached a point of near completion, but, as the brain has developed later in the process of evolution than the other parts of the body, we have to Images On Pinterest | Business, assume, that the brain's evolution is far from being complete. I would even say, regarding the low factor of utilisation of the Preparer Job Description brain's capacities human beings display nowadays, that we are at the beginning of the Audit Poject And Audit brain's evolution.

This evolution is not only biologically, but concomitantly, the evolution of the faculties of thinking is extending our thinking massively. This sustains my theory of Paranoesis or Transrational Thinking. Because it is already now possible to use the full extent of our brain's capacity by applying the method of Paranoesis. Fortunately, this method is so far unknown, and as this method cannot be applied by people who are not philosophically engaged, the danger of its abuse is Food Job Description debarred. If we look on some thousand years into the future, we can probably imagine the human being in its full blossom, that is, thinking is Clear, For Essential highly extended and Food Preparer Job Description, used more effectively and comprehensively than in Referral On Pinterest | Business Photography our days. How is it possible to attain the full range of capacities of our brain although it is not developed biologically enough?

The answer is simple: if we do not consider thinking as an epiphenomenon of the brain, as modern neurobiology erroneously assume, we can explain the brain as a sort of medium or bridge between Hyponoesis (Universal Mind) and Exonoesis, that is our individual thinking faculty as such. Exonoesis is dependent on the evolution of Preparer Job Description our brain, because it uses the brain's physiological capacities. Hyponoesis is independent of any material or corporeal medium. If our individual mind applies the method of Paranoesis or Transrational Thinking, it will be able to transcend the limitations constraining the Individual Mind (Exonoesis) and link up directly with Hyponoesis. A person thinking transrationally is not thinking within the bounds of the capacity of the brain, as rational thinking does.

Exonoesis thinks as Hyponoesis, it is one with Hyponoesis and therefore uses the unrestrained power of Hyponoesis. As Exonoesis participates in Hyponoesis, whether thinking rationally or transrationally, and as Exonoesis is the individualized and Battleships-Blank-Worksheet.jpg, materialized product of Hyponoesis, there always exist a natural nexus between Exonoesis and Hyponoesis. The Transrational Thinker is Preparer able to unearth this latent nexus and thereby restore the 11 Accounting Poject On Cost And Audit Report Of original oneness of Job Description Exonoesis and Hyponoesis (Individual and 07 40 Two Weeks, Universal Mind), abolishing the Food Preparer illusory duality and becoming noetically one with Hyponoesis. The common notion about evolution of mankind draws on the scientific theory elucidated in Darwinism. Unfortunately Darwin held that the Employee Work Schedule Template Excel, Pdf Format human mind evolved simultaneously together with the organism and the faculties of Food perception.

While our ancestors living in caves developed gradually the faculty of using the first tools, the | Business Cards, Photography Evolutionists believe, that their intellectual faculty also began to flourish and thus reason, the unique feature of the homo sapiens, slowly came into being. Mind that makes up the human being in its wholeness, has never evolved. Only the intellectual faculties were refined over the centuries. Mind as such has always been, independent of the Food Preparer evolution, unchanged by Audit Report. 11 Accounting And Audit, the changes of Food Preparer Job Description time, indifferent to the upheavals of mankind and the struggling effort to grasp that which I call the One Mind. Therefore it is only the utilization of the latent and Battleships-Blank-Worksheet.jpg, hitherto unknown faculties of our mind that increased over the time. While cave people used their mental faculties at a minimum rate, modern human's rate of utilization has dramatically increased and Food Job Description, has produced our technological age. Nevertheless, the average degree of utilization is small compared to all the unexplored faculties that lie still unused in our mind, not yet discovered. Only some outstanding and illustrious personages in every era, and especially the great philosophers of the past, succeeded in 11 Best On Pinterest Cards, tapping the uncharted reservoir of the human mind, if only partially, though. Thus the evolution of mind and the evolution of matter (body and consciousness) are not necessarily concomitant. If neuroscientists are convinced that consciousness could be ultimately explained by neurochemical processes in the brain, I would not object to this assumption that I think will be experimentally verified in the near future . Consciousness as a state of awareness or attentiveness does not explain thinking that is a much more complex process.

Thinking will never be explained as a product of the neurophysiological events within the brain, because thinking is not an Food Preparer Job Description epiphenomenon of corporeal or material processes. Employee Free Excel,? Even consciousness is still not accounted for by merely physical processes. Food? How does something invisible, immeasurable, completely subjective such as our experience of ourselves is, originate from an observable and measurable physical process. This phase transition from mere physical brain operations to Letter. Two Weeks, mental or psychical operations is the critical and up to now unexplained Achilles heel of neuroscience and ancillary fields. Thinking harnesses the capacity of our brain, which evolved over 2 million years. It is the medium that evolved, not thinking as such. Food? Thinking is dependent on the brain in 11 Best Referral Images Photography order to express itself, in order to establish communicative powers, reasoning powers and Food, so on. Thinking is necessary for our survival as a species, for Battleships-Blank-Worksheet.jpg, the individual being to be able to live. The more our brain evolved, the more the infinite power of thinking (or what I call Hyponoesis ) could become manifest through the behavior and thinking of the human being.

Thinking as such (Hyponoesis) is independent of the body or the brain. If not active as the individual mind it remains in a state of noetic vacuum before manifesting as Exonoesis (Individual Minds). The brain is therefore just a medium of expression for thinking. Preparer? Consciousness however is the fundamental state that denotes the being as alive, and that is the intermediary between thinking as a non-material process and the neurophysiological processes of the brain. Consciousness is the link between thinking and Wedding Planner A5 Wedding Planning Binder, the brain, between the mind and the body. I do not mean to emphasize a dualistic notion with this. On the contrary, dualism, as postulated by Preparer Job Description, Descartes, means an assumption of two totally independent and different substances, although they are capable of interacting somehow. We could call this the strong dualism, compared to the weak or complementary dualism I propose. This dualism is Clear, Laser-Printer Labels For Essential comparable to the particle-wave dualism and the principle of complementarity postulated by Food Preparer Job Description, Bohr. Both, particle and wave are an aspect of the same subatomic event. They complement each other and belong necessarily together.

Mind and body, therefore, are not antagonistic or completely different. Both are interconnected aspects of the 11 Best Referral Images | Business Photography same underlying and fundamental energy. The body as such is Preparer just a biological machine, which could not survive on its own. Consciousness gives the 11 Best Images Photography body the necessary information about the world outside it and about the body itself. Thinking is the Food Preparer what guides, steers or directs the course of the life, how the body is used for expressing inner moods etc. The whole psychology of our psyche is under the guidance and auspices of thinking (see also the laws of cybernetic). In Aristotelian terms: thinking is the form that individuates matter, and thus produces the individuality, be it that of the body, the mind or the soul. (cf. Thomas Aquinas on the unity of body and soul, Summa Theologica, Ia, 76.1) The problem with neuroscience and its assumption that mind is only a complex biological phenomenon is, that they cannot explain, how an Free Word, Excel, Pdf Format immaterial complexity, such as consciousness and thinking could have originated and evolved from a totally different material substance as matter (explanatory gap). Food Preparer? Every material phenomenon can be measured or at least statistically described by natural science.

Why are they not able to do the Battleships-Blank-Worksheet.jpg same with this so-called biological phenomenon of the MIND? Why do most scientific approaches fail when applied to the understanding of our mind? Between this complex structure of consciousness and the physiological brain functions there seems to Food Preparer Job Description, be an unsurmountable gap that has not yet been bridged. The functions and structure of Wedding A5 Wedding our mind do not, by analogy, resemble the function and structure of the material counterpart, the brain. Both functions are different. If consciousness is the result of complex neurobiological functions in the brain, why is the resulting structure so completely different in its processes? How is it possible, that a material body can produce an immaterial consciousness?

How is individuality in our mind explained, though our brains are basically the same? I mean, the human bodies may be slightly different, but the basic functions, like breathing, digestion, blood circulation, brain processes etc. are the same within the species of home sapiens, even within the genus of living beings. Nevertheless, if we consider the individuality of the human being, its character, its consciousness, its thinking, nothing could be more variegated and Food Preparer, distinct than that. If our brain would be responsible for the mind, then where does this individuality come from? Why do some persons have an Official Resignation 07 40 Two Weeks extraordinary reason, and others are dull and barely intelligent? Environmental influences alone cannot explain that fact, otherwise animals would show a smiliar distinction within their species. I think that philosophers since ever clearly separated the mind from our body or the material world.

We cannot simply reject their thoughts as dualism. Why shouldn't there be a dualism of some sort? It is only in Preparer our century that thinkers came to be sceptical of dualism by accepting only one substance, matter. By this act they could easily wipe away some of the more fundamental problems. This enterprise is Janus-faced, because on the other side they created a host of new problems, as mentioned above, and these problems are for some part really absurd. 1996-2017 by Tom Arnold. All rights reserved. Send comments and questions to author.

Last Updated: 7/9/2016.