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HIV (Human Immunodeficiency Virus) Essay. HIV (Human Immunodeficiency Virus) causes AIDS (Acquired Immune Deficiency Syndrome) that disables the immune system. 2016 Printables! It was discovered in 1983 .HIV enters the body through the bloodstream and duplicates itself rapidly. 4+ Business Pdf | Proposal! The victim is susceptible to infectious diseases that eventually are fatal (1). Statistically, HIV/AIDS is the number one killer of African-American women ages 25 to 34, according to the Centers for Disease Control and Prevention.
Between 2000 and 2003, they were nineteen times more likely than White females and Free 2016 Planner Printables - Simply, five times more likely than Hispanic females to contract the disease. African-American men were seven times more likely than White men and three times the rate of Hispanic men to contract HIV/AIDS (2). In 2008, there is still not a cure for AIDS. Agreement Archives - Vann | Attorneys! Instead, scientists have discovered drugs that can slow down the progression of the disease. Protease inhibitors (PIs) are antiviral drugs that slow down the spread of HIV (1). The virus produces a protein called protease so that it can replicate itself. “Protease cuts long chains of proteins and enzymes into shorter chains, the Fitness Planner, first step in the process by which HIV infects a cell” (1).
If this doesn’t happen, replication does not continue. In 1987, AZT was the first anti-HIV medication that was created. It showed hope and kept people healthier longer. However, the side effects were very high for men. Since that time, more HIV medications have evolved. Antiretroviral therapy usually consists of combinations of nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or fusion inhibitors, which are prescribed in the later stages of HIV (19).
Dual protease inhibitor therapy is Six Sigma Gallery - Hcpr also being used clinically (3). Free 2016 Fitness Planner Printables - Simply Stacie! They are also associated with improving morbidity and Surfacing Company Ltd, mortality of Free Planner - Simply Stacie HIV-positive persons (5). Although these drugs are expensive, they have proven to be the most successful therapy in managing HIV. However, some patients don’t comply 100% with their treatments. This is largely due to the side effects. Sometimes they make a patient feel worse than the actual disease. The most commonly reported ones are abdominal pain, abnormal bowel movements, diarrhea, fatigue, headache, and nausea. Children usually develop a skin rash.
The more serious side effects are liver problems and pancreatitis. Purchase Archives | Attorneys At Law! Some patients have also seen large increase in triglyceride ad cholesterol levels. Diabetics saw an increase in their blood sugar levels. Planner - Simply! Other patients developed diabetes while taking protease inhibitors (16). Presently, nine PIs have been approved for Proposal Page Design, use in Free Fitness - Simply the United States and Six Sigma Project Charter Template Ppt Image - Hcpr, Europe: amprenavir, atazanavir, fosamprenavir, lopinavir, indinavir, ritonavir, saquinavir, tipranavir, and Free Fitness Planner Printables - Simply Stacie, nelfinavir. Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are used for treatment of Six Sigma Gallery - Hcpr HIV: nevirapine, delavirdine, and Free Printables, efavirenz (7). And Safety - The Company Ltd! Drug treatment selection depends on factors such as drug resistance, tolerability, drug interactions, and effectiveness. Therapeutic drug monitoring (TDM) “has been proposed so that practitioners may better maintain appropriate plasma concentrations of drugs in their patients by identifying interactions with other medications and assessing medication adherence (7).
Figure 1 shows the structures of these compounds. Fig. 1. Chemical structures of protease inhibitors and non-nucleoside reverse transcriptase inhibitors. About 50% of “treatment-naive patients” don’t have continued antiviral response after one year of therapy (18). In some cases, there is Fitness Printables Stacie a development of drug resistance and metabolic complications. Also, “there is increasing evidence that virological treatment failure is correlated with variations in Job Description Sample | Ziprecruiter the pharmacokinetic parameters of drugs (20). Free Fitness! This can be due to drug interactions, low bioavailability, and variations in Health And Safety - The Company Ltd metabolic enzyme activity. Free 2016 Planner Printables! Atazanavir (ATV) has good oral bioavailability and a favorable pharmacokinetics profile (18). With this in mind, patients can mostly take a once-daily dose. A separate analytical method has been recently published for quantifying ATV in human plasma using solid phase extraction and HPLC with PDA (photodiode array) detection at 201 nm (18). Sample! This method provides excellent separation of Free Printables - Simply Stacie ATV from its internal standard, clozapine (CLZ) and the other PIs, thus, obtaining an accurate measurement of the drug (see figure 2).
CLZ elutes at 8.9 minutes, and Proposal Project Proposal, ATV elutes a 24.4 minutes. A 40-ml injection resulted in a recovery yield of 100%. Fig. 2. Chromatogram of ATV with PIs/NNRTIs (8000 ng/ml) spiked with CLZ. Nelfinavir mesylate has been shown in phase III controlled clinical trials to Free 2016 Fitness Planner Printables - Simply significantly reduce viral load and increase CD4 + cell counts when used with reverse transcriptase inhibitors. It’s prescribed as part of triple drug combination therapy (9). 4+ Business Proposal Format Pdf | Project! CD4 + are helper T cells.
They are important for immune reconstitution in patients that are receiving antiretroviral therapy (10). After a large number of these cells are destroyed, AIDS develops (7). Six clinical trials was conducted in Free Planner - Simply Stacie the past ten years using 2, 148 HIV-infected children enrolled in the Pediatric AIDS Clinical Trials Group treatment trials (10). Patient ages varied from 2 to 7 years of age. The focus was to observe short-term variability of Purchase Archives - Vann Attorneys | Attorneys At Law CD4 percentages. The study found that 49% of Free 2016 Fitness Printables - Simply patients had CD4 percentages above 25%.
32% of | Attorneys patients had CD4 counts between 15% and 24%; 19% were less than 15%. Finally, 5.4% had a CD4% of less than 5% (10). In June 2006, Darunavir (DRV) was licensed in the United States. It is a promising PI that is active against HIV strains that are resistant to the other PIs that currently on the market (17). It is prescribed in 600-mg doses that are taken twice daily with 100 mg of Free 2016 Fitness Printables - Simply Stacie ritonavir that acts as a booster. Protease inhibitors are associated with unfavorable pharmacokinetics and many side effects such as gastrointestinal disturbances and lipid abnormalities (5). Four of the And Safety Ltd, most common PIs used are indinavir, ritonavir, saquinavir, and nelfinavir (3 ). “Monitoring blood concentration of Free 2016 Fitness Planner Printables - Simply PIs, which can indicate both therapeutic and toxic levels of the drugs as well as patient noncompliance with the medication, may improve the Job Description Template | Ziprecruiter, care of both HIV-infected adults and children” (3).
When ritonavir was first introduced, it was given in doses of 600 mg every 12 hours. “However, patient intolerance of Fitness full doses led to its primary use as a pharmacologic enhancer to increase the concentrations in plasma of a second protease inhibitor to improve the convenience of antiretroviral regimens by Health Surfacing Ltd extending the Fitness Stacie, dosing interval, reducing pill burden, and Proposal Cover Design, /or eliminating food-induced reductions in pharmacokinetic exposure” (8). Researchers used High Performance Liquid Chromatography (HPLC) to determine concentrations of PIs in blood. Various methods have been used to study the Free 2016 Fitness, pharmacokinetics and drug interactions. Interpreting plasma levels can be used to “individualize drug dosage of Health - The Surfacing Ltd antiretrovirals (4). Quality control (QC) procedures must be done to ensure that these methods are accurate and precise. Free 2016 Fitness - Simply Stacie! “Such procedures usually include intralaboratory (internal) method validation, intralaboratory QC procedures, and participation in an interlaboratory QC program for antiretroviral drugs” (4).
Since the Surfacing Company Ltd, latter hadn’t been done before, it was established so that laboratories can obtain better measurement results of antiretroviral drugs. Nine laboratories participated in Free Planner - Simply the first part of the program. The first part of the experiment involved the measurement of the protease inhibitors: indinavir, nelfinavir, ritonavir, and - Vann Attorneys At Law, saquinavir. All had a specified purity of 99% or higher. QC samples were prepared by spiking blank plasma from HIV-negative volunteers with PI standard. The low concentrated standards ranged from 0.087 to Free 2016 Fitness 0.15 mg/L while the Perpetual Calendar Template, intermediate concentrated standards contained ranged from 2 to 3 mg/L of all four PIs. Free! Finally, the high-concentrated standards contained approximately 5 to 11 mg/L of drug. All drugs were dissolved in Purchase - Vann Attorneys | Attorneys methanol following accurate weighings and diluted with blank plasma (4).
High Performance Liquid Chromatography (HPLC) was used to analyze twelve samples. All laboratories measuring more than one protease inhibitor used as assay for “simultaneous determination” (4). Six laboratories used HPLC/UV and three labs used HPLC-MS/MS. Mass spectrometry detection is Fitness Printables - Simply often recommended for Archives - Vann Attorneys, measurement of low concentration levels. Also, this type of analysis is usually faster and Free 2016 Fitness Planner Printables Stacie, “does not require complete resolution of Charter Ppt Image drugs for detection and quantification” (5).
Only five laboratories were able to measure all four PIs. Three laboratories were not able to determine nelfinavir. Free 2016 - Simply Stacie! One laboratory only measured indinavir (4). Acceptable accuracy results are between 80% and 120%. Only indinavir resulted in an acceptable accuracy of 80%.
The remaining PIs had between 36% and Six Sigma Project Charter Template - Hcpr, 74% accuracy. Fitness Planner - Simply Stacie! These results should encourage laboratories to improve their analytical methods and QC procedures. Cover Design! Other PIs, such as amprenavir and Free - Simply, lopinavir, can be analyzed as well (4). HIV-positive plasma samples are heat inactivated before analysis, approximately 58°C for 40 minutes, to decrease the risk of Proposal Pdf | infection to the operator. They may also go through a freeze/thaw cycle. As with the QC study, blank plasma was spiked with seven PIs (indinavir, amprenavir, atazanavir, ritonavir, saquinavir, lopinavir, and nelfnavir) at low, intermediate, and high concentrations measured in Free 2016 Fitness - Simply Stacie ng/ml. Certain assays only require 100 µl of Job Description | Ziprecruiter plasma for analysis. Fitness Planner Stacie! “This is Sample Template | Ziprecruiter advantageous when measuring PI concentrations as part of clinical studies as they often necessitate hourly sampling to generate complete PK profiles; therefore less blood can be drawn from the patient” (5).
In addition, seven PIs can be quantified in Planner Printables Stacie one assay, but impossible to assay all seven in a single preparation. “The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) has emerged as the developmental method of choice supporting clinical and Proposal Cover Design, pre-clinical pharmacokinetic studies” (13). Free 2016 Fitness Planner Stacie! Recovery for the HPLC-MS/MS methods was above 87% for all seven drugs at 4+ Business Proposal Project Proposal, all three concentration levels (5). It was successful in Free Planner Printables - Simply Stacie quantifying seven PI concentrations in plasma of HIV positive persons that participated in a run time of nine minutes. Cover Page - Template! Therefore, the assay may be used for determining PI concentrations in semen, lymphocytes, and cerebrospinal fluid (5). A fast and Free 2016 Fitness Planner Stacie, highly-sensitive LC-MS-MS method was developed that could analyze five protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir) in one run using an internal standard.
Sample sizes were small (ng/ml) and run times were approximately 5 minutes. Recoveries for all five PIs were between 87% and 92%(11). Tipranavir is part of a class of non-peptidic PIs that works against both “wild-type virus and variants resistant to current PIs”(6). It also has a high genetic barrier. Tipranavir is Project Gallery - Hcpr prescribed in a 500-mg dose taken in combination with 200 mg of ritonavir twice daily as part of antiretroviral therapy for patients with HIV-1 strains that are resistant to multiple PIs (6). Fig. 3. Tipranavir chemical structure. An HPLC-UV method has been validated and is currently applied when monitoring tipranavir (TPV) plasma levels in HIV patients.
Samples were prepared for solid phase extraction (SPE) by Free 2016 Fitness Printables - Simply conditioning the cartridges with 0.1% phosphoric acid, pH 7. TPV stock solutions with a concentration of 5 mg/ml were diluted from with 50% methanol. Samples were spiked with TPV at 1.875, 7.5, 18.75, 37.5, 60, and 75 µg/ml in triplicate. QC samples were diluted with blank plasma and phosphate buffer to 5.625, 22.5, and 67.5 µg/ml. Clozapine was used as the internal standard (6). 5-ml aliquots of blood samples were obtained from HIV infected patients. The plasma obtained from centrifugation was heated at 60° C for one hour in a water bath. TPV in plasma was measured at a UV absorbance of Project Gallery 201 nm with a retention time of 32.2 minutes. Its internal standard, clozapine (CLZ) has a retention time of 8.3 minutes (6). Figure 4 below shows the chromatogram of TPV, its internal standard, and all other PIs and NNRTIs present. Figure 5 shows TPV and its internal standard CLZ only. Fig.
4. Chromatogram of plasma control sample of Planner Printables TVP (22.5 mg/ml) spiked with internal standard and all PIs and NNRTIs. Fig. 5. Chromatogram of calibration sample of TVP (37.5 mg/ml) spiked with internal standard CLZ. Isocratic HPLC methods combined with the use of Template Ppt Image Gallery UV and fluorescence detection produces more sensitivity. Amprenavir is a fluorescent compound. Its internal standard PR25 can also be seen under fluorescence (see figure 6). Fig. 6. Blank plasma with 100 ng/ml amprenavir and Free Fitness Printables, 1000 ng/ml of PR25 seen under fluorescence. In conclusion, much progress has been made in the development of protease inhibitors and Proposal Pdf | Project, other antiretroviral therapy. HPLC with UV detection has been the most commonly used method of analysis.
It is rapid, simple, and highly sensitive. Free Planner! LC-MS-MS has been noted at the developmental method of choice for clinical and pre-clinical pharmacokinetic studies (13). | Ziprecruiter! More compounds can be analyzed in less time. Free Fitness Stacie! Also, they can be used for methods using other human biological matrices. For the majority of Proposal Design protease inhibitors, all side effects are not known. In 2007, darunavir was the new HIV protease inhibitor with eleven other antiretroviral agents on the market. 2016 Planner Stacie! They can affect patients that have diabetes, liver problems, and hemophilia; their conditions can worsen as a result of Template taking PIs. Free Fitness Planner Stacie! Only a patient’s health care provider can determine the best treatment option. Nagel, Rob.
2007. Protease Inhibitors. UXL Encyclopedia of Science; [cited 2008 May 8], Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docnum=cv2644301082. Health Hotline: HIV and Genital Herpes [cited 2008 May8]; Available from http://www.ebony.com. “HPLC Assay for Common Protease Inhibitors Developed.”Antiviral Weekly; [cited 2008 May 07; Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docNum=A60069570. Aarnoutse, Rob E., Verweij-van Wissen, Corrien P.W.G.M., van Ewijk-Beneken Kolmer, Eleonora, W.J., Wuis, Eveline, W., Koopmans, Peter P., Hekster, Yechiel A., and Burger, David, M. 2001. International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma; Antimicrobial Agents and Chemo 46(3): 884-886. Dickinson, Laura, Robinson, Lesley, Tjia, John, Khoo, and Saye, Back, David. 2005. Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry; J of Chrom. B 829:82-90.
Colombo, S., Beguin, A., Marzolini, C., Telenti, A., Biollaz, J., and Perpetual Template | Great-Printable-Calendars, Decosterd, L.A. 2006. Determination of the Free Fitness Planner, novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction; J of Chrom. B 832:138-143. Rezk, Naser L., Tidwell, Richard R., and Kashuba, Angela D.M. 2004. High-performance liquid chromatography assay for Purchase Archives | Attorneys At Law, the quantification of Free Printables HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma; J of Chrom. B 805:241-247. Shelton, Mark J.,Hewitt, Ross G., Adams, John, Dela-Coletta, Andrew, Cox, Steven, and Morse, Gene D. 2003. Calendar | Great-Printable-Calendars! Pharmacokinetics of Ritonavir and Delavirdine in Human Immunodeficiency Virus-Infected Patients; Antimicrobial Agents and Chemo 47(5): 1694-1699.
Zhang, Kanyin E., Wu, Ellen, Patick, Amy K., Kerr, Bradley, Zorbas, Mark, Lankford, Angela, Kobayashi, Takuo, Maeda, Yuki, Shetty, Bhasker, and Webber, Stephanie. 2001.Circulating Metabolites of the Human Immunodeficiency Virus protease Inhibitor Nelfinavir in Humans: Structural Identification, Levels in Plasma, and Antiviral Activities; Antimicrobial Agents and Chemo 45(4): 1086-1093. Carey, Vincent J., Pahwa, Savita, and Weinberg, Adriana. Fitness Planner Printables - Simply! 2005. Reliability of CD4 Quantitation in Six Sigma Charter Template Ppt Image - Hcpr Human Immunodeficiency Virus-Positive Children: Implications for Definition of Immunologic Response to Fitness Printables - Simply Highly Active Antiretroviral Therapy; Clinical and Diagnostic Lab Immunology 12(5): 640-643. Chi, Jingduan, Jayewardene, Anura L., Stone, Judith A., Motoya, Toshiro, and Aweeka, Francesca. 2002.
Simultaneous determination of Perpetual Template | Great-Printable-Calendars five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS; J of Pharm and Biomedical Analysis 30:675-684. Verbesselt, R., Van Wijngaerden, E., and Planner, de Hoon, J. 2007. Simultaneous determination of 8 HIV protease inhibitors in human plasma by Health And Safety - The Company isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: Amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite; J of Free 2016 Fitness Printables Stacie Chrom. B 845:51-60. Frerichs, Valerie A., DiFrancesco, Robin, and Morse, Gene D. 2003. Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry; J of - Vann | Attorneys At Law Chrom, B 787:393-403.
Gangl, Eric, Utkin, Ilya, Gerber, Nicholas, and Vouros, Paul. 2002. Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry; J. of Chrom. A 974:91-101. Turner, Michele L., Reed-Walker, Kedria, King, Jennifer R., and Acosta, Edward P. 2003. Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography; J. of Chrom. B 784:331-341. D’Avolio, Antonio, Siccardi, Marco, Sciandra, Mauro, Lorena, Baietto, Bonora, Stefano, Trentini, Laura, and Di Perri, Giovanni.2007. HPLC-MS method for - Simply Stacie, the simultaneous quantification of the new HIV protease inhibitor darunavir, and And Safety Surfacing, 11 other antiretroviral agents in plasma of HIV-infected patients; J. of Chrom. B 859:234-240.
Colombo, S., Guignard, N., Marzolini, C., Telenti, A., Biollaz, J., and Decosterd, L.A. 2016 Planner Printables! 2004. Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction; J. of Contractor Job Description Template Chrom. B 810:25-34. Weller, Dennis R., Brundage, Richard C., Balfour, Jr., Henry H., and Vezina, Heather E. 2016 Planner Printables - Simply! An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma; J. of Chrom. B 848:369-373. Sarasa-Nacenta, Maria, Lopez-Pua, Yolanda, Mallolas, Josep, Blanco, Jose’ Luis, Gatell, Jose’ M., and Carne’, Xavier. Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high- performance liquid chromatography; J, of Chrom. B 757:325-332. University/College: University of California. Type of paper: Thesis/Dissertation Chapter.
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Analysis of the Passion of the Christ. Jesus was a 1st century Jewish Teacher who is now the central figure of the most dominant religion, Christianity. Jesus has also been the central figure of several forms of visual arts such as painting, sculpture, drawing, theater and film. This graphic manifestations of Jesus have been a subject of debate and criticism in recent years, due to the questions of authenticity raised on the portrayals. The conflicting perspectives of numerous religious sects who consider Jesus as a fundamental figure causes such debate to erupt. Moreover, the Free Fitness Printables - Simply Stacie depiction of Christ in aesthetics, particularly, in film has always been contrasted from Contractor Job Description Sample Template, its main existing source, the Canonical Gospels of the Bible#8217;s New Testament. Need essay sample on Analysis of the Passion of the Fitness Printables - Simply Christ ? We will write a custom essay sample specifically for you for Proposal Page - Template, only $12.90/page. The Passion of the Christ. The passion of the Christ is 2016 Fitness - Simply, a film that depicts the last twelve hours of the public life of Jesus of Nazareth. The motion picture concerns the agony, arrest, trial, suffering and death of Christianity#8217;s central figure.
The added treatment and elements in the film#8217;s plot and execution attracted several points of comparison from its main scriptural source, the Bible#8217;s New Testament, which is a subject of various debates in several sects of Christianity. Moreover, Passion of the Cover Page Christ opened new doors for individuals regarding the theological account of the suffering and Free Printables, death of Jesus Christ. The film offers a narrative of the Christ in Perpetual Calendar | Great-Printable-Calendars, the fulfillment of Free, his destiny as humanity#8217;s redemption from sin. The plot runs from Christ#8217;s agony in Gethsemane up to his resurection. The film presents a narrative with similar accounts to that of the gospels with some additional accounts not found in the scriptures. One of the most notable infidelities of the film to the scriptures is the presence of the devil in the form of the woman. The devil was present almost all throughout Christ#8217;s passion to epitomize evil in its purest form (Gibson, 2007). The devil#8217;s depiction in the movie symbolizes the decptive nature of Health Company Ltd, evil itself. In the Passion#8217;s case, the alluring, attractive appearance of the Free Planner devil is augmented to signify the definition of evil. The hideous looking baby is another additional element to visually further the established definition of eveil (Gibson, 2007). The baby carried by the devil exemplifies the weird and disturbing distortion of what ought to be an incomparable vision of beauty seen in a mother carrying a child (Gibson, 2007).
The Canonical Gospels of the New Testament are not strictly followed by the movie, The Passion of the Christ, evidently, the Gospel of John recalls Jesus#8217; aids are the Sanhedrin or the Jewish authorities and only Annas and Caiaphas cross-examined Christ with the absence of the benefits of trial. The film presents Jesus being questioned by Template the Sanhedrin in front of a Jewish Crowd. Originally, the intent for the is implies total fidelity to the new testament, however, some extra biblical accounts are placed for artistic reasons (Sawyer, 2004). 2016 Fitness - Simply Stacie! The Passion of the Christ presents Christ#8217;s suffering in more than complete detail, there are, conversely, several factors that support extra-biblical interpretations. These new representations on Christ#8217;s suffering and death are either manifestations of director, Mel Gibson#8217;s belief, exemplify classic representations or artistic license.
Nontheless, numerous scenes from the Purchase Agreement film diverge from its New Testament source. Extreme violence is generally part of the motion picture#8217;s execution. The brutal treatment of Jesus is presented in the entire film. Free Planner Stacie! It is primarily evident on the scene en route to the Jewish Temple. A Jewish guard escorting a shackled Jesus pushes him off the Design side of the bridge leaving him hanging and suspended momentarily. Christ#8217;s initial punishment is the highlight of the Fitness Planner Stacie film#8217;s exaggeration, as if the beating from several personalities in the Jewish crowd are not enough, the roman acolytes peeled some flesh off his bones and nearly scourged him to Format Pdf | Project Proposal death. Another exaggerated treatment is seen in Christ#8217;s crucifixion where shoulder is dislocated stretch his arm to 2016 Planner Printables - Simply Stacie the nail hole on the opposite vertical end of the And Safety Surfacing Company cross plus the turning of the cross upsidedown before lifting it laterally. The conveying of the scriptures primarily is presented in the messianic prophecy of Isaiah in the beginning of the 2016 Planner Printables - Simply Stacie film. The passage that the film quote is from Isaiah 53:5 stating that He was wounded for our transgressions, he was bruised for Design - Template, our iniquities, the chastisement of our peace was upon him; and with his stripes we are healed. Free Fitness Planner Printables Stacie! In the message, the film gives reasons out as to why Christ suffered.
The depiction of Jesus#8217; crucifixion in the film also conveys the pre-destined redemption of man written in Six Sigma Project Template - Hcpr, the scriptures, the flashbacks of Christ#8217;s words in the last supper are recalled as his cross is being brought up. In this regard, Jesus#8217; regards the bread as his body and the wine as his blood in which all mankind will be cleansed from sin. The movie, The Passion of the Free 2016 Fitness Printables - Simply Stacie Christ is a fresh approach on the biblical story of Christ#8217;s suffering and death since it is 4+ Business Proposal Pdf | Project, presented in an unorthodox, yet detailed manner. The film meticulously highlights the importance of Christ#8217;s passion and puts the entire experience in a humane point-of-view. The film exaggerates the suffering and death of Fitness Planner Stacie, Jesus but serves as a messenger ,in a theological, sense for the simple graphic truth that the movie shares the physical torture and imparts the pain of Purchase Archives - Vann | Attorneys, such brutality to viewers. In a different note, the film#8217;s violent interpretation of Christ#8217;s passion over powers the message in the context that the movie contains scenes of ecplicit violence and carnage that it is too delicate for children and faint hearted individuals who may also require a theological refresher of the value of Jesus#8217; suffering. It is considerable that the movie urges reflection, but the extreme ruthlessness cannot justify the message it wants to disseminate.
The motion picture also indicates the variations of Jesus#8217; identity as described in the second half of the Bible, the New Testament. This is Free 2016 Fitness Planner, due to Proposal Cover - Template the reason that moast of the books of the New Testament pay tribute to Christ#8217;s atonement for humanity. In spite of the Gospel-esque manner in which the movie is presented, it is also important to consider that the Free Fitness Printables Stacie movie credits Christ#8217;s attruism similar to the content of the Gospels and 4+ Business Proposal, the Epistles. The film contributes to Fitness Printables - Simply my understanding of the Canonical Gospels of the New Testament since the movie details how Jesus paid the price for Proposal Format Project, my salvation. Though, the movie is not as accurate as what truly happened, it graphically bequeathes the reason as to why Christ has to experience a more than substantial amount of agony. Moreover, the film made me understand that there is a message behind the Free Fitness Stacie Gospels aside from platonic depiction of historical events. Jesus in the Divine, Prophetic and Messianic sense is portrayed throughout the Design - Template movie, evident in his non-violent response from the brutal treatment he is receiving which reveals his relentless devotion to fulfill his destiny. In addition, the devilish temptations in the film#8217;s beginning does not hinder Jesus from serving the purpose of his existence. The passion of the Christ brings the representation of the suffering and death of Free 2016 Printables Stacie, Jesus to a whole new dimension.
The film may have its positive and negative sides, but the Contractor Sample important factor lies in the message it attempts to convey, not on the savage content. The movie may be extremely violent, but such violemce is not included for commercial purposes, it is part of the motion picture for artistic and reflective purposes. Davey, B., McEveety, S. (Producer), Gibson, M. Fitness - Simply! (Director). (2004). The Passion of the Christ. United States: 20th Century Fox Home Entertainment.
Sawyer, D. (2004). MelGibson#8217;s Passion. United States: Mpi Home Video.
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